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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2016 Sep 3;132:41–46. doi: 10.1016/j.prostaglandins.2016.09.001

Fig. 1.

Fig. 1

Consecutive oxygenation of arachidonic acid by 5-LOX and COX-2 gives a diendoperoxide as the major and 5,11- and 5,15-diHETE as by-products. Further enzymatic or non-enzymatic transformation of the di-endoperoxide gives HKD2 and HKE2. The diendoperoxide can be cleaved by FeCl2 or hematin into three aldehydes. COX-2 reacts 5S-HETE with 3 molecules of oxygen, and their incorporation into the di-endoperoxide and subsequent fate in the HKs and other products is marked by the different colors.