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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: JACC Heart Fail. 2017 Feb 1;5(3):194–203. doi: 10.1016/j.jchf.2016.12.007

Central Illustration. Proposed Cardioprotective Mechanisms of Vaccination.

Central Illustration

Pathophysiologic mechanisms involved in vaccination-induced cardioprotection include inhibition of oxidized low-density lipoprotein uptake by molecular mimicry from pneumococcal vaccination-induced antibodiy production and the attenuation of chronic inflammation, a pro-atherogenic process, in influenza vaccination. TNF-a = tumor necrosis factor-alpha, IL-1B = interleukin 1-beta, LDL = low-density lipoprotein, MMP = matrix metalloproteinases, NO = nitric oxide.