Table 1.
A: Comparison of users and non-users of angiotensin converting enzyme-I/angiotensin receptor blockers (ACE-I/ARBs) at baseline; B: Among those with history of ACE-I/ARB use, comparison of discontinuers and continuers of ACE-I/ARB use at last visit.
| Clinical Factors | A: Among cohort (N=851) | B: Among those with history of use (N=611) | ||
|---|---|---|---|---|
|
| ||||
| ACE-I/ARB use at baseline (N=472)a,b | No ACE-I/ARB use at baseline (N=379)a,b | Continuer (N=463)a,b | Discontinuer (N=148)a,b | |
| Demographics | ||||
|
| ||||
| Age (years) | 12 (9–15) | 10 (6–14) | 16 (12–18) | 15 (13–18) |
| Male Sex | 59% | 65% | 59% | 66% |
| Black Race | 21% | 23% | 22% | 21% |
| Insurance | 97% | 98% | 97% | 97% |
| Household Income | ||||
| ≤$30,000 | 35% | 34% | 32% | 36% |
| $30001 to $75000 | 34% | 37% | 31% | 30% |
| >$75,000 | 31% | 29% | 37% | 34% |
| Family size≤3 members | 32% | 27% | 41% | 37% |
| Emergency room visit in past year | 38% | 44% | 37% | 37% |
|
| ||||
| Clinical Characteristics | ||||
|
| ||||
| Glomerular DX | 45% | 13% | 42% | 26% |
| GFR (mL/min|1.73 m2) | 53 (38–73) | 52 (39–70) | 47 (33–67) | 26 (18–44) |
| uP/C | 0.39 (0.14–1.16) | 0.31 (0.11–0.87) | 0.45 (0.16–1.49) | 1.54 (0.35–3.48) |
| Anemia | 33% | 20% | 34% | 51% |
| Elevated BP | 25% | 36% | 23% | 41% |
| High normal BP | 48% | 54% | 47% | 45% |
| Elevated Phosphate | 16% | 10% | 19% | 44% |
| Elevated Potassium | 10% | 5% | 9% | 9% |
| Acidosis | 54% | 49% | 70% | 78% |
| # of medications | 4 (2–6) | 3 (2–5) | 4 (2–6) | 6 (4–9) |
Definitions: uP/C= urine protein/creatinine ratio, anemia= hemoglobin<5th %ile, Elevated BP (blood pressure)=systolic or diastolic BP>90th %ile, high normal BP= systolic or diastolic BP between the 50th and the 90th percentile, Elevated phosphate =serum phosphate> 6.5 mg/dL for children <13 years old and > 4.5 mg/dL for children > 13 years, Elevated potassium= serum potassiums > 5.2 mEq/L, acidosis= serum CO2 < 22 mEq/L.
GFR, glomerular filtration rate
Values are medians and interquartile ranges or %
Bold signifies P<0.05 for comparisons between users and non-users in A and between continuers and discontinuers in B from Wilcoxon rank test or Fisher’s exact test.