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Coversin reduced local myocardial IL-1β production. IL-1β obtained by microdialysis was induced in the area at risk (AAR) and not the control region after 4 h of reperfusion. Coversin treatment (filled bars) significantly reduced IL-1β in the AAR by 80% in comparison to placebo treated animals (open bars). Values presented as mean ± SEM [n = 7 (placebo) and n = 5 (coversin)]. Two-way ANOVA with post hoc Bonferroni correction for multiple testing
