Fig. 8.

Analysis of acetylcholine-induced vasorelaxation of aortic rings (A) and albuminuria (B) in db/db mice and after treatment with dbm bone marrow-derived cells (Txdb) or db/db bone marrow-derived cells exposed in vivo (Txdb-Ebs in vivo) and ex vivo (Txdb-Ebs ex vivo) to the organoselenic antioxidant and peroxinitrite scavenger ebselen. Note that adoptive transfer of syngeneic bone marrow-derived cells improves macro- and microvasculopathy. P < 0.05 compared with db/db (*), with db/db and Txdb (**), and with TxCM (#). Reprinted with permission from Ref. 12.