Fig. 2.

Role of Krüppel-like factor 15 in podocyte differentiation. We highlight the pathway by which Krüppel-like factor 15 (KLF15) mediates retinoic acid (RA) and glucocorticoids (GCs)-induced restoration of podocyte differentiation markers [actin cytoskeleton, increased expression of podocyte-specific cytoskeleton and slit diaphragm proteins (Nephrin, Podocin, and Synaptopodin)] under cell stress. GR, glucocorticoid receptor; cAMP, cyclic adenosine monophosphate; PKA, protein kinase A; CREB, cAMP response element-binding protein; GRE, GC response element; CRE, cAMP response element.