Fig. 2.

Microarray analysis of 2 wk-treated dystrophic het mice with a nonspecific or specific MR antagonist plus lisinopril results in a comparable number of gene-expression changes. Treatment with lisinopril plus spironolactone (LS) results in decreased expression of 46 genes and increased expression of 20 genes (66 genes total) compared with untreated het. Eplerenone plus lisinopril (EL) treatment results in a comparable number of gene-expression changes, 23 increased and 47 decreased (70 genes total). Thirty-three (50%) of these gene changes are conserved in EL-treated mice compared with untreated het. Treatment with standard-of-care prednisolone (Pred) results in 374 gene-expression changes, 122 increased and 252 decreased compared with untreated het. Only 62 genes of these genes are conserved with LS- or EL-treated mice versus untreated het; 312 genes are specific to prednisolone treatment. Ten gene-expression changes are present in both the LS and EL compared with untreated het but not in the prednisolone group. *Genes that are changed in the opposite directions with MR antagonist and prednisolone treatment. Dbp is represented in both the group of 10 gene changes conserved between LS and EL and as the gene-expression change (*) conserved with prednisolone but in the opposite direction.