Table 1.
Fold changes of gene-expression differences conserved in microarray comparing quadriceps muscles from lisinopril plus spironolactone (LS) and eplerenone plus lisinopril (EL) mice versus untreated het controls (Un)
| Gene Symbol | Full Gene Name | Fold Change (LS/Un) | Fold Change (EL/Un) |
|---|---|---|---|
| Immune response and homeostasis | |||
| Cd14 | CD14 antigen | −2.8 | −2.8 |
| Cd80 | CD80 antigen | −2.9 | −3.1 |
| Csf2rb | Colony-stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | −3.8 | −3.5 |
| Fcgr3 | Fc receptor, IgG, low-affinity III | −2.2 | −2.2 |
| Il6 | Interleukin 6 | −3.9 | −2.9 |
| Mt1 | Metallothionein 1 | −2.1 | −2.3 |
| Nfkbia | Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha | −2.8 | −2.1 |
| Tfpi2 | Tissue factor pathway inhibitor 2 | −2.3 | −2.4 |
| Thbs1 | Thrombospondin 1 | −6.2 | −6.8 |
| Scd2 | Stearoyl-coenzyme A desaturase 2 | 4.1 | 4.4 |
| Wfdc17 | Whey acidic protein (WAP) 4-disulfide core domain 17 | −2.1 | −2.6 |
| Regulation of transcription | |||
| Dbp | D Site albumin promoter-binding protein | 4.2 | 3.1 |
| Litaf | LPS-induced TNF-α factor | −2.4 | −2.3 |
| Mxd1 | Myc-associated factor X (MAX) dimerization protein 1 | −2.3 | −2.6 |
| Nr1d1 | Nuclear receptor subfamily 1, group D, member 1 | 2.4 | 2.3 |
| Nr4a3 | Nuclear receptor subfamily 4, group A, member 3 | −5.6 | −4.0 |
| Ion binding and transport | |||
| Adamts1 | A disintegrin-like and metallopeptidase (reprolysin-type) with thrombospondin type 1 motif, 1 | −2.5 | −2.2 |
| Mt2 | Metallothionein 2 | −2.4 | −2.8 |
| Pim1 | Proviral integration site 1 | −2.0 | −2.4 |
| Scd1 | Stearoyl-coenzyme A desaturase 1 | 7.1 | 5.3 |
| Zfp36 | Zinc finger protein 36 | −4.7 | −3.5 |
| Apoptosis and proteolysis | |||
| Clu | Clusterin | −2.1 | −2.9 |
| Alternative splicing | |||
| Asb15 | Ankyrin repeat and SOCS box-containing 15 | 2.8 | 3.4 |
| Plaur | Plasminogen activator, urokinase receptor | −2.4 | −2.7 |
| Prkag3 | Protein kinase, AMP-activated, gamma 3 noncatalytic subunit | 3.1 | 3.0 |
| Transmembrane | |||
| Atp1b4 | ATPase, Na+/K+ transporting, beta 4 polypeptide | 2.0 | 2.6 |
| Ifitm1 | Interferon-induced transmembrane protein 1 | −2.2 | −2.1 |
| Lrtm1 | Leucine-rich repeats and transmembrane domain 1 | 2.5 | 3.0 |
| Ms4a4a | Membrane-spanning 4-domains, subfamily A, member 4A | −2.7 | −2.8 |
| Tmem252 | Transmembrane protein 252 | −2.9 | −3.0 |
| Unknown or specific functions | |||
| Dusp5 | Dual-specificity phosphatase 5 | −2.5 | −2.3 |
| Hdc | Histidine decarboxylase | −6.6 | −6.0 |
| Sec14l5 | SEC14-like 5 (Saccharomyces cerevisiae) | 2.7 | 2.1 |
Genes were functionally clustered using the Functional Annotation clustering tool from the Database for Annotation, Visualization and Integrated Discovery (DAVID). Positive fold changes indicate that gene expression was increased with treatment and vice versa. The 10 gene-expression changes conserved between LS and EL, but not changed by prednisolone, are shown in bold.