Table 3.
Gene Symbol | Full Gene Name | Fold Change (Pred/Un) |
---|---|---|
Immune response/regulation of immune response | ||
Cd274 | CD274 antigen | −2.0 |
Cd300ld | CD300 molecule-like family, member d | −2.2 |
Clec4n | C-Type lectin domain family 4, member n | −4.1 |
Cmip | c-Maf-inducing protein | −2.1 |
Ddx58 | Asp-Glu-Ala-Asp (DEAD) box polypeptide 58 | −2.1 |
Fcgr2b | Fc receptor, IgG, low-affinity IIb | −2.6 |
H2-Eb1 | Histocompatibility 2, class II antigen E β | −2.7 |
Ifih1 | Interferon-induced with helicase C domain 1 | −2.4 |
Ifit1 | Interferon-induced protein with tetratricopeptide repeats 1 | −2.7 |
Ifit2 | Interferon-induced protein with tetratricopeptide repeats 2 | −2.2 |
Ifit3 | Interferon-induced protein with tetratricopeptide repeats 3 | −2.7 |
Oas2 | 2′-5′ Oligoadenylate synthetase 2 | −5.5 |
Oasl2 | 2′-5′ Oligoadenylate synthetase-like 2 | −3.2 |
Rnf125 | Ring finger protein 125 | −3.1 |
Rsad2 | Radical S-adenosyl methionine domain-containing 2 | −3.4 |
Samhd1 | SAM domain and HD domain 1 | −2.0 |
Tpd52 | Tumor protein D52 | −2.2 |
Trim25 | Tripartite motif-containing 25 | −2.4 |
Cytokines with chemokine activity | ||
Adamts9 | A disintegrin-like and metallopeptidase (reprolysin-type) with thrombospondin type 1 motif, 9 | −5.0 |
Ccl8 | Chemokine (C–C motif) ligand 8 | −4.1 |
Ccl11 | Chemokine (C–C motif) ligand 11 | −3.2 |
Cfb | Complement factor B | −2.1 |
Cxcl1 | Chemokine (C–X–C motif) ligand 1 | −2.7 |
Cxcl9 | Chemokine (C–X–C motif) ligand 9 | −8.0 |
Cxcl13 | Chemokine (C–X–C motif) ligand 13 | 6.9 |
Cxcr4 | Chemokine (C–X–C motif) receptor 4 | −2.9 |
Egf | Epidermal growth factor | 2.1 |
Entpd1 | Ectonucleoside triphosphate diphosphohydrolase 1 | −2.1 |
Hck | Hemopoietic cell kinase | −2.0 |
Hif1a | Hypoxia-inducible factor 1, alpha subunit | −3.7 |
Igfbp3 | Insulin-like growth factor-binding protein 3 | 2.7 |
Igh-VJ558 | Immunoglobulin heavy chain (J558 family) | 2.1 |
Il1r1 | Interleukin 1 receptor, type I | −3.6 |
Il13ra1 | Interleukin 13 receptor, alpha 1 | −2.5 |
Il33 | Interleukin 33 | −8.7 |
Irf7 | Interferon regulatory factor 7 | −2.6 |
Lep | Leptin | 2.3 |
Lrrc32 | Leucine-rich repeat containing 32 | −2.2 |
Ly86 | Lymphocyte antigen 86 | −2.8 |
Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | −3.1 |
Rap1b | RAS-related protein 1b | −2.1 |
Stat1 | Signal transducer and activator of transcription 1 | −2.5 |
Stat2 | Signal transducer and activator of transcription 2 | −2.9 |
Thbd | Thrombomodulin | −2.3 |
Regulation of transcription | ||
Ankrd2 | Ankyrin repeat domain 2 (stretch-responsive muscle) | 3.5 |
Bach1 | BTB and CNC homology 1 | −2.0 |
Baz1a | Bromodomain adjacent to zinc finger domain 1A | −2.6 |
Bhlhe40 | Basic helix-loop-helix family, member e40 | −2.1 |
C7 | Complement component 7 | 3.0 |
Ccnl1 | Cyclin L1 | −2.0 |
Crem | cAMP-responsive element modulator | −2.1 |
Ell2 | Elongation factor RNA polymerase II 2 | −2.0 |
Erg | Avian erythroblastosis virus E-26 (v-ets) oncogene related | −2.3 |
Fos | FBJ osteosarcoma oncogene | −5.1 |
Klf2 | Kruppel-like factor 2 (lung) | −3.0 |
Mafb | v-maf Musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) | −2.8 |
Mamstr | MEF2-activating motif and SAP domain-containing transcriptional regulator | 2.0 |
Mnda | Myeloid cell nuclear differentiation antigen | −4.5 |
Nrip1 | Nuclear receptor-interacting protein 1 | −2.8 |
Parp14 | Poly (ADP-ribose) polymerase family, member 14 | −2.4 |
Per1 | Period circadian clock 1 | −6.4 |
Perm1 | PPARGC1 and ESRR-induced regulator, muscle 1 | 2.5 |
Rcor3 | REST corepressor 3 | 2.2 |
Rcor3 | REST corepressor 3 | 2.4 |
Rorc | RAR-related orphan receptor gamma | 2.4 |
Rxrg | Retinoid X receptor gamma | 3.2 |
Tigd4 | Tigger transposable element-derived 4 | 2.3 |
Ion binding and transport | ||
Ano5 | Anoctamin 5 | 2.4 |
Apobec2 | Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 | 2.3 |
Cacna1s | Calcium channel, voltage-dependent, L type, alpha 1S subunit | 2.0 |
Car14 | Carbonic anhydrase 14 | 6.6 |
Cd93 | CD93 antigen | −2.5 |
Cdh5 | Cadherin 5 | −3.7 |
Clcn1 | Chloride channel 1 | 2.6 |
Csrp3 | Cysteine and glycine-rich protein 3 | 2.4 |
Cyp27a1 | Cytochrome P450, family 27, subfamily a, polypeptide 1 | 2.1 |
Dtna | Dystrobrevin alpha | 2.0 |
Fmo2 | Flavin containing monooxygenase 2 | 2.1 |
Gabrr2 | Gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 | 2.1 |
Kcng4 | Potassium voltage-gated channel, subfamily G, member 4 | 2.7 |
Kcnj2 | Potassium inwardly rectifying channel, subfamily J, member 2 | 3.5 |
Kcnj12 | Potassium inwardly rectifying channel, subfamily J, member 12 | 2.7 |
Mpi | Mannose phosphate isomerase | 2.3 |
Mrc1 | Mannose receptor, C type 1 | −3.2 |
Parp12 | Poly (ADP-ribose) polymerase family, member 12 | −2.2 |
Pgm1 | Phosphoglucomutase 1 | −2.1 |
Plod2 | Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 | −2.4 |
Ppp2r3a | Protein phosphatase 2, regulatory subunit B, alpha | 2.1 |
Prkd2 | Protein kinase D2 | −2.4 |
Rnf213 | Ring finger protein 213 | −3.4 |
S100a11 | S100 calcium-binding protein A11 (calgizzarin) | −2.5 |
Slc10a6 | Solute carrier family 10 (sodium/bile acid cotransporter family), member 6 | −3.3 |
Slc16a3 | Solute carrier family 16 (monocarboxylic acid transporters), member 3 | 2.4 |
Slc25a25 | Solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 | −3.5 |
Slc30a2 | Solute carrier family 30 (zinc transporter), member 2 | 2.6 |
Slc38a3 | Solute carrier family 38, member 3 | 2.0 |
Slc38a4 | Solute carrier family 38, member 4 | 2.4 |
Sln | Sarcolipin | 3.8 |
Trim54 | Tripartite motif-containing 54 | 2.1 |
Zfp366 | Zinc finger protein 366 | −2.0 |
Zswim6 | Zinc finger SWIM-type containing 6 | −2.3 |
GTPase activity | ||
Arhgap20 | Rho GTPase-activating protein 20 | 4.1 |
Gbp2 | Guanylate-binding protein 2 | −2.2 |
Gbp3 | Guanylate-binding protein 3 | −2.3 |
Gbp7 | Guanylate-binding protein 7 | −2.3 |
Gbp8 | Guanylate-binding protein 8 | −2.3 |
Gbp9 | Guanylate-binding protein 9 | −2.7 |
Gbp10 | Guanylate-binding protein 10 | −2.9 |
Gbp11 | Guanylate-binding protein 11 | −2.1 |
Gm12185 | Predicted gene 12185 | −2.5 |
Gvin1 | GTPase, very large interferon-inducible 1 | −2.3 |
Rac2 | RAS-related C3 botulinum substrate 2 | −2.1 |
Rapgef5 | Rap guanine nucleotide-exchange factor (GEF) 5 | −2.9 |
Rgs5 | Regulator of G-protein signaling 5 | −2.7 |
Tgtp2 | T Cell-specific GTPase 2 | −3.2 |
Apoptosis and proteolysis/regulation of apoptosis | ||
Agt | Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 2.1 |
Aldh1a1 | Aldehyde dehydrogenase family 1, subfamily A1 | 5.9 |
Asb2 | Ankyrin repeat and SOCS box-containing 2 | 2.3 |
Asb11 | Ankyrin repeat and SOCS box-containing 11 | 2.2 |
Asb12 | Ankyrin repeat and SOCS box-containing 12 | 2.1 |
Atp1a2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 2.1 |
Bcl3 | B Cell leukemia/lymphoma 3 | 3.2 |
Ctla2a | Cytotoxic T lymphocyte-associated protein 2 alpha | −2.4 |
Ctla2b | Cytotoxic T lymphocyte-associated protein 2β | −3.1 |
Dapk2 | Death-associated protein kinase 2 | 2.2 |
Ddit4 | DNA damage-inducible transcript 4 | −5.2 |
Dpep1 | Dipeptidase 1 (renal) | 2.5 |
Egfbp2 | Epidermal growth factor binding protein type B | 4.0 |
Egln3 | Egl-9 family hypoxia-inducible factor 3 | 2.1 |
Eif2ak2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | −2.6 |
Errfi1 | ERBB receptor feedback inhibitor 1 | −11.5 |
Fbxo32 | F-Box protein 32 | 2.7 |
Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | −2.0 |
Fcgr1 | Fc receptor, IgG, high affinity I | −6.1 |
Gadd45a | Growth arrest and DNA-damage-inducible 45 alpha | −2.0 |
Gadd45g | Growth arrest and DNA-damage-inducible 45 gamma | −10.0 |
Herc3 | Hect domain and RLD 3 | 2.0 |
Hmox1 | Heme oxygenase (decycling) 1 | −4.4 |
Ifi204 | Interferon-activated gene 204 | −3.8 |
Mmp3 | Matrix metallopeptidase 3 | −3.6 |
Myc | Myelocytomatosis oncogene | −2.5 |
Nr4a1 | Nuclear receptor subfamily 4, group A, member 1 | −5.3 |
Pdia3 | Protein disulfide isomerase-associated 3 | −2.3 |
Pnp | Purine-nucleoside phosphorylase | −2.7 |
Sh3rf2 | SH3 domain-containing ring finger 2 | 3.5 |
Smtnl1 | Smoothelin-like 1 | 2.7 |
Stk17b | Serine/threonine kinase 17b (apoptosis inducing) | −2.5 |
Tsc22d3 | TSC22 domain family, member 3 | −3.4 |
Usp18 | Ubiquitin-specific peptidase 18 | −2.8 |
Xaf1 | X-Linked inhibitor of apoptosis (XIAP)-associated factor 1 | −2.9 |
Drug metabolism | ||
Gsta3 | Glutathione S-transferase, alpha 3 | 2.6 |
Gstk1 | Glutathione S-transferase kappa 1 | 2.1 |
Mgst3 | Microsomal glutathione S-transferase 3 | 2.1 |
Cytoskeleton | ||
Arpc3 | Actin-related protein 2/3 complex, subunit 3 | −2.1 |
Cnn2 | Calponin 2 | −2.5 |
Fhl3 | Four and one-half LIM domains 3 | 2.6 |
Msn | Moesin | −2.2 |
Myo5c | Myosin VC | 2.2 |
Myoz1 | Myozenin 1 | 2.2 |
Ptpn4 | Protein tyrosine phosphatase, nonreceptor type 4 | 2.2 |
Tagln2 | Transgelin 2 | −2.1 |
Tpm4 | Tropomyosin 4 | −2.2 |
Ttll7 | Tubulin tyrosine ligase-like family, member 7 | 2.6 |
Cell adhesion | ||
Col15a1 | Collagen, type XV, alpha 1 | −2.5 |
Cytip | Cytohesin 1-interacting protein | −2.6 |
Lgals3bp | Lectin, galactoside-binding, soluble, 3 binding protein | −2.1 |
Vcan | Versican | −2.6 |
Behavioral response to stimulus | ||
Amot | Angiomotin | 2.1 |
Amot | Angiomotin | 2.3 |
Sncg | Synuclein, gamma | 2.3 |
Cell migration and motility | ||
Bin2 | Bridging integrator 2 | −2.1 |
Ctgf | Connective tissue growth factor | −2.3 |
Dnaja1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | −3.0 |
Itga1 | Integrin alpha 1 | −2.7 |
Itga6 | Integrin alpha 6 | −2.5 |
Myh9 | Myosin, heavy polypeptide 9, nonmuscle | −2.3 |
Nus1 | Nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | −2.3 |
Ret | Ret proto-oncogene | −2.7 |
Rhob | Ras homolog gene family, member B | −2.0 |
S1pr1 | Sphingosine-1-phosphate receptor 1 | −3.2 |
Sema6c | Sema domain, transmembrane domain (TM), and cytoplasmic domain (semaphorin), 6C | 2.2 |
Alternative splicing | ||
BC094916 | cDNA sequence BC094916 | −3.3 |
Coq10b | Coenzyme Q10 homolog B (S. cerevisiae) | −2.9 |
Far1 | Fatty acyl CoA reductase 1 | −2.1 |
Htra3 | HtrA serine peptidase 3 | 2.2 |
Ifi203 | Interferon-activated gene 203 | −2.8 |
Lgals9 | Lectin, galactose-binding, soluble 9 | −3.0 |
Lpcat2 | Lysophosphatidylcholine acyltransferase 2 | −2.0 |
Midn | Midnolin | −2.3 |
Mgat4a | Mannoside acetylglucosaminyltransferase 4, isoenzyme A | −2.1 |
Nnat | Neuronatin | 3.2 |
Picalm | Phosphatidylinositol-binding clathrin assembly protein | −2.3 |
Pla2g4e | Phospholipase A2, group IVE | 2.2 |
Ptbp3 | Polypyrimidine tract-binding protein 3 | −2.2 |
Rtp4 | Receptor transporter protein 4 | −2.5 |
Sp100 | Nuclear antigen Sp100 | −2.5 |
Trib1 | Tribbles homolog 1 (Drosophila) | −2.2 |
Trp53inp2 | Transformation-related protein 53-inducible nuclear protein 2 | 2.2 |
Zbp1 | Z-DNA-binding protein 1 | −2.9 |
Transmembrane | ||
Abcb4 | ATP-binding cassette, subfamily B (MDR/TAP), member 4 | 2.3 |
Alox5ap | Arachidonate 5-lipoxygenase activating protein | −3.8 |
Aqp4 | Aquaporin 4 | 2.5 |
B3galt2 | UDP-Gal: βGlcNAc β 1,3-galactosyltransferase, polypeptide 2 | 2.6 |
B4galt5 | UDP-Gal: βGlcNAc β 1,4-galactosyltransferase, polypeptide 5 | −4.6 |
Bst2 | Bone marrow stromal cell antigen 2 | −5.3 |
Cd53 | CD53 antigen | −2.7 |
Chsy1 | Chondroitin sulfate synthase 1 | −2.2 |
Cpt1b | Carnitine palmitoyltransferase 1b, muscle | 2.1 |
Ctxn3 | Cortexin 3 | 3.6 |
Emp1 | Epithelial membrane protein 1 | −2.7 |
Gpr65 | G-Protein-coupled receptor 65 | −2.4 |
Gprc5a | G-Protein-coupled receptor, family C, group 5, member A | −2.1 |
Has1 | Hyaluronan synthase1 | −2.2 |
Ier3 | Immediate early response 3 | −2.7 |
Ifitm3 | Interferon-induced transmembrane protein 3 | −2.3 |
Mc5r | Melanocortin 5 receptor | 3.0 |
Ms4a4b | Membrane-spanning 4-domains, subfamily A, member 4B | −2.3 |
Ms4a4c | Membrane-spanning 4-domains, subfamily A, member 4C | −7.6 |
Ms4a6b | Membrane-spanning 4-domains, subfamily A, member 6B | −2.6 |
Ms4a6c | Membrane-spanning 4-domains, subfamily A, member 6C | −2.5 |
Ms4a6d | Membrane-spanning 4-domains, subfamily A, member 6D | −3.5 |
Slc2a4 | Solute carrier family 2 (facilitated glucose transporter), member 4 | 3.0 |
Slc7a8 | Solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 | −2.7 |
Sptlc2 | Serine palmitoyltransferase, long-chain base subunit 2 | −2.1 |
St3gal5 | ST3 β-galactoside alpha-2,3-sialyltransferase 5 | 2.2 |
Tecr | Trans-2,3-enoyl-CoA reductase | 2.1 |
Tyrobp | TYRO protein tyrosine kinase binding protein | −2.1 |
Unknown or specific functions | ||
1810011O10Rik | RIKEN cDNA 1810011O10 gene | −2.2 |
2310002L09Rik | RIKEN cDNA 2310002L09 gene | 2.3 |
8430408G22Rik | RIKEN cDNA 8430408G22 gene | −7.3 |
9430020K01Rik | RIKEN cDNA 9430020K01 gene | −2.1 |
A730049H05Rik | RIKEN cDNA A730049H05 gene | −2.1 |
AA467197 | Expressed sequence AA467197 | −2.1 |
AI607873 | Expressed sequence AI607873 | −3.5 |
Aldh1a7 | Aldehyde dehydrogenase family 1, subfamily A7 | 2.9 |
Apold1 | Apolipoprotein L domain-containing 1 | −9.8 |
Arrdc2 | Arrestin domain-containing 2 | −2.5 |
Cox7b2 | Cytochrome c oxidase subunit VIIb2 | −2.2 |
Dcaf4 | DDB1 and CUL4-associated factor 4 | 2.1 |
Dennd4a | DENN/MADD-containing 4A | −2.3 |
Dusp1 | Dual-specificity phosphatase 1 | −3.7 |
Dusp10 | Dual-specificity phosphatase 10 | 2.9 |
Eif1a | Eukaryotic translation initiation factor 1A | −2.2 |
Erdr1 | Erythroid differentiation regulator 1 | −10.0 |
Exd2 | Exonuclease 3–5 domain-containing 2 | 2.7 |
Fam46a | Family with sequence similarity 46, member A | −2.0 |
Fam101b | Family with sequence similarity 101, member B | −2.3 |
Fcrls | Fc receptor-like S, scavenger receptor | −3.0 |
Gbas | Glioblastoma-amplified sequence | 2.1 |
Gm22 | Predicted gene, 22 | −2.2 |
Gm4899 | Predicted gene, 4899 | −2.4 |
Gm4955 | Predicted gene, 4955 | −3.4 |
Gm6377 | Predicted gene, 6377 | −2.5 |
Gm6904 | Predicted gene, 6904 | −2.1 |
Gm10110 | Predicted gene, 10110 | 2.2 |
Gm10999 | Predicted gene, 10999 | 2.0 |
Gm11037 | Predicted gene, 11037 | −2.4 |
Gm11710 | Predicted gene, 11710 | −2.0 |
Gm11711 | Predicted gene, 11711 | −2.0 |
Gm21742 | Predicted gene, 21742 | −9.7 |
Gm21748 | Predicted gene, 21748 | −56.6 |
Gm21750 | Predicted gene, 21750 | 2.1 |
Gm21857 | Predicted gene, 21857 | −4.2 |
Gm21860 | Predicted gene, 21860 | −56.6 |
Gm21887 | Predicted gene, 21887 | −9.3 |
Gys1 | Glycogen synthase 1, muscle | 2.1 |
Herc6 | Hect domain and RLD 6 | −2.6 |
I830012O16Rik | RIKEN cDNA I830012O16 gene | −3.5 |
Ifi44 | Interferon-induced protein 44 | −6.0 |
Ifi202b | Interferon-activated gene 202B | −3.4 |
Inmt | Indolethylamine N-methyltransferase | 2.9 |
Kbtbd13 | Kelch repeat and BTB (POZ) domain containing 13 | 2.1 |
Klhdc3 | Kelch domain-containing 3 | 2.2 |
Klhl38 | Kelch-like 38 | 2.6 |
Lrrc14b | Leucine-rich repeat containing 14B | 2.2 |
Lsmem2 | Leucine-rich single-pass membrane protein 2 | 2.0 |
Mettl7a1 | Methyltransferase-like 7A1 | 2.4 |
Mettl21e | Methyltransferase-like 21E | 6.6 |
Mndal | Myeloid nuclear differentiation antigen like | −2.2 |
Mup3 | Major urinary protein 3 | 2.4 |
Myom3 | Myomesin family, member 3 | 2.3 |
Odf3l2 | Outer dense fiber of sperm tails 3-like 2 | 5.3 |
Pde4b | Phosphodiesterase 4B, cAMP specific | −2.1 |
Phf11b | PHD finger protein 11B | −3.1 |
Phf11d | PHD finger protein 11D | −2.3 |
Plac8 | Placenta-specific 8 | −2.5 |
Pnp2 | Purine-nucleoside phosphorylase 2 | −2.7 |
Ppp1r3c | Protein phosphatase 1, regulatory (inhibitor) subunit 3C | 3.0 |
Prob1 | Proline-rich basic protein 1 | 2.1 |
Ptma | Prothymosin alpha | −2.4 |
Pydc3 | Pyrin domain-containing 3 | −3.0 |
Pydc4 | Pyrin domain-containing 4 | −3.3 |
Retnlg | Resistin-like gamma | −5.7 |
Rilpl1 | Rab-interacting lysosomal protein-like 1 | 2.2 |
Rragd | Ras-related GTP-binding D | 2.1 |
Sbk2 | SH3-binding domain kinase family, member 2 | 2.6 |
Serpine1 | Serine (or cysteine) peptidase inhibitor, clade E, member 1 | −9.6 |
Sh3pxd2b | SH3 and PX domains 2B | −2.0 |
Slfn1 | Schlafen 1 | −3.2 |
Slfn2 | Schlafen 2 | −3.7 |
Slfn4 | Schlafen 4 | −9.7 |
Slfn5 | Schlafen 5 | −2.3 |
Slfn8 | Schlafen 8 | −2.7 |
Tpm3-rs7 | Tropomyosin 3, related sequence 7 | −2.6 |
Tra2a | Transformer 2 alpha homolog (Drosophila) | −2.5 |
Trim30a | Tripartite motif-containing 30A | −3.9 |
Trim30b | Tripartite motif-containing 30B | −3.6 |
Trim30c | Tripartite motif-containing 30C | −3.4 |
Trim30d | Tripartite motif-containing 30D | −3.8 |
Wee1 | WEE 1 homolog 1 (Schizosaccharomyces pombe) | −2.1 |
Xlr3b | X-Linked lymphocyte-regulated 3B | 2.4 |
Xlr3c | X-Linked lymphocyte-regulated 3C | 2.2 |
This list excludes the gene-expression changes also conserved with either LS or EL treatment, listed in Table 2. Genes were functionally clustered using the Functional Annotation clustering tool from the Database for Annotation, Visualization and Integrated Discovery (DAVID). Positive fold changes indicate that gene expression was increased with treatment and vice versa.