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. 2016 Nov 23;312(2):C155–C168. doi: 10.1152/ajpcell.00269.2016

Table 3.

Fold changes of gene-expression differences specific to microarray comparing quadriceps muscles from prednisolone (Pred)-treated het mice versus untreated het controls (Un)

Gene Symbol Full Gene Name Fold Change (Pred/Un)
Immune response/regulation of immune response
 Cd274 CD274 antigen −2.0
 Cd300ld CD300 molecule-like family, member d −2.2
 Clec4n C-Type lectin domain family 4, member n −4.1
 Cmip c-Maf-inducing protein −2.1
 Ddx58 Asp-Glu-Ala-Asp (DEAD) box polypeptide 58 −2.1
 Fcgr2b Fc receptor, IgG, low-affinity IIb −2.6
 H2-Eb1 Histocompatibility 2, class II antigen E β −2.7
 Ifih1 Interferon-induced with helicase C domain 1 −2.4
 Ifit1 Interferon-induced protein with tetratricopeptide repeats 1 −2.7
 Ifit2 Interferon-induced protein with tetratricopeptide repeats 2 −2.2
 Ifit3 Interferon-induced protein with tetratricopeptide repeats 3 −2.7
 Oas2 2′-5′ Oligoadenylate synthetase 2 −5.5
 Oasl2 2′-5′ Oligoadenylate synthetase-like 2 −3.2
 Rnf125 Ring finger protein 125 −3.1
 Rsad2 Radical S-adenosyl methionine domain-containing 2 −3.4
 Samhd1 SAM domain and HD domain 1 −2.0
 Tpd52 Tumor protein D52 −2.2
 Trim25 Tripartite motif-containing 25 −2.4
Cytokines with chemokine activity
 Adamts9 A disintegrin-like and metallopeptidase (reprolysin-type) with thrombospondin type 1 motif, 9 −5.0
 Ccl8 Chemokine (C–C motif) ligand 8 −4.1
 Ccl11 Chemokine (C–C motif) ligand 11 −3.2
 Cfb Complement factor B −2.1
 Cxcl1 Chemokine (C–X–C motif) ligand 1 −2.7
 Cxcl9 Chemokine (C–X–C motif) ligand 9 −8.0
 Cxcl13 Chemokine (C–X–C motif) ligand 13 6.9
 Cxcr4 Chemokine (C–X–C motif) receptor 4 −2.9
 Egf Epidermal growth factor 2.1
 Entpd1 Ectonucleoside triphosphate diphosphohydrolase 1 −2.1
 Hck Hemopoietic cell kinase −2.0
 Hif1a Hypoxia-inducible factor 1, alpha subunit −3.7
 Igfbp3 Insulin-like growth factor-binding protein 3 2.7
 Igh-VJ558 Immunoglobulin heavy chain (J558 family) 2.1
 Il1r1 Interleukin 1 receptor, type I −3.6
 Il13ra1 Interleukin 13 receptor, alpha 1 −2.5
 Il33 Interleukin 33 −8.7
 Irf7 Interferon regulatory factor 7 −2.6
 Lep Leptin 2.3
 Lrrc32 Leucine-rich repeat containing 32 −2.2
 Ly86 Lymphocyte antigen 86 −2.8
 Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog −3.1
 Rap1b RAS-related protein 1b −2.1
 Stat1 Signal transducer and activator of transcription 1 −2.5
 Stat2 Signal transducer and activator of transcription 2 −2.9
 Thbd Thrombomodulin −2.3
Regulation of transcription
 Ankrd2 Ankyrin repeat domain 2 (stretch-responsive muscle) 3.5
 Bach1 BTB and CNC homology 1 −2.0
 Baz1a Bromodomain adjacent to zinc finger domain 1A −2.6
 Bhlhe40 Basic helix-loop-helix family, member e40 −2.1
 C7 Complement component 7 3.0
 Ccnl1 Cyclin L1 −2.0
 Crem cAMP-responsive element modulator −2.1
 Ell2 Elongation factor RNA polymerase II 2 −2.0
 Erg Avian erythroblastosis virus E-26 (v-ets) oncogene related −2.3
 Fos FBJ osteosarcoma oncogene −5.1
 Klf2 Kruppel-like factor 2 (lung) −3.0
 Mafb v-maf Musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) −2.8
 Mamstr MEF2-activating motif and SAP domain-containing transcriptional regulator 2.0
 Mnda Myeloid cell nuclear differentiation antigen −4.5
 Nrip1 Nuclear receptor-interacting protein 1 −2.8
 Parp14 Poly (ADP-ribose) polymerase family, member 14 −2.4
 Per1 Period circadian clock 1 −6.4
 Perm1 PPARGC1 and ESRR-induced regulator, muscle 1 2.5
 Rcor3 REST corepressor 3 2.2
 Rcor3 REST corepressor 3 2.4
 Rorc RAR-related orphan receptor gamma 2.4
 Rxrg Retinoid X receptor gamma 3.2
 Tigd4 Tigger transposable element-derived 4 2.3
Ion binding and transport
 Ano5 Anoctamin 5 2.4
 Apobec2 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 2.3
 Cacna1s Calcium channel, voltage-dependent, L type, alpha 1S subunit 2.0
 Car14 Carbonic anhydrase 14 6.6
 Cd93 CD93 antigen −2.5
 Cdh5 Cadherin 5 −3.7
 Clcn1 Chloride channel 1 2.6
 Csrp3 Cysteine and glycine-rich protein 3 2.4
 Cyp27a1 Cytochrome P450, family 27, subfamily a, polypeptide 1 2.1
 Dtna Dystrobrevin alpha 2.0
 Fmo2 Flavin containing monooxygenase 2 2.1
 Gabrr2 Gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 2.1
 Kcng4 Potassium voltage-gated channel, subfamily G, member 4 2.7
 Kcnj2 Potassium inwardly rectifying channel, subfamily J, member 2 3.5
 Kcnj12 Potassium inwardly rectifying channel, subfamily J, member 12 2.7
 Mpi Mannose phosphate isomerase 2.3
 Mrc1 Mannose receptor, C type 1 −3.2
 Parp12 Poly (ADP-ribose) polymerase family, member 12 −2.2
 Pgm1 Phosphoglucomutase 1 −2.1
 Plod2 Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 −2.4
 Ppp2r3a Protein phosphatase 2, regulatory subunit B, alpha 2.1
 Prkd2 Protein kinase D2 −2.4
 Rnf213 Ring finger protein 213 −3.4
 S100a11 S100 calcium-binding protein A11 (calgizzarin) −2.5
 Slc10a6 Solute carrier family 10 (sodium/bile acid cotransporter family), member 6 −3.3
 Slc16a3 Solute carrier family 16 (monocarboxylic acid transporters), member 3 2.4
 Slc25a25 Solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 −3.5
 Slc30a2 Solute carrier family 30 (zinc transporter), member 2 2.6
 Slc38a3 Solute carrier family 38, member 3 2.0
 Slc38a4 Solute carrier family 38, member 4 2.4
 Sln Sarcolipin 3.8
 Trim54 Tripartite motif-containing 54 2.1
 Zfp366 Zinc finger protein 366 −2.0
 Zswim6 Zinc finger SWIM-type containing 6 −2.3
GTPase activity
 Arhgap20 Rho GTPase-activating protein 20 4.1
 Gbp2 Guanylate-binding protein 2 −2.2
 Gbp3 Guanylate-binding protein 3 −2.3
 Gbp7 Guanylate-binding protein 7 −2.3
 Gbp8 Guanylate-binding protein 8 −2.3
 Gbp9 Guanylate-binding protein 9 −2.7
 Gbp10 Guanylate-binding protein 10 −2.9
 Gbp11 Guanylate-binding protein 11 −2.1
 Gm12185 Predicted gene 12185 −2.5
 Gvin1 GTPase, very large interferon-inducible 1 −2.3
 Rac2 RAS-related C3 botulinum substrate 2 −2.1
 Rapgef5 Rap guanine nucleotide-exchange factor (GEF) 5 −2.9
 Rgs5 Regulator of G-protein signaling 5 −2.7
 Tgtp2 T Cell-specific GTPase 2 −3.2
Apoptosis and proteolysis/regulation of apoptosis
 Agt Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.1
 Aldh1a1 Aldehyde dehydrogenase family 1, subfamily A1 5.9
 Asb2 Ankyrin repeat and SOCS box-containing 2 2.3
 Asb11 Ankyrin repeat and SOCS box-containing 11 2.2
 Asb12 Ankyrin repeat and SOCS box-containing 12 2.1
 Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 2.1
 Bcl3 B Cell leukemia/lymphoma 3 3.2
 Ctla2a Cytotoxic T lymphocyte-associated protein 2 alpha −2.4
 Ctla2b Cytotoxic T lymphocyte-associated protein 2β −3.1
 Dapk2 Death-associated protein kinase 2 2.2
 Ddit4 DNA damage-inducible transcript 4 −5.2
 Dpep1 Dipeptidase 1 (renal) 2.5
 Egfbp2 Epidermal growth factor binding protein type B 4.0
 Egln3 Egl-9 family hypoxia-inducible factor 3 2.1
 Eif2ak2 Eukaryotic translation initiation factor 2-alpha kinase 2 −2.6
 Errfi1 ERBB receptor feedback inhibitor 1 −11.5
 Fbxo32 F-Box protein 32 2.7
 Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide −2.0
 Fcgr1 Fc receptor, IgG, high affinity I −6.1
 Gadd45a Growth arrest and DNA-damage-inducible 45 alpha −2.0
 Gadd45g Growth arrest and DNA-damage-inducible 45 gamma −10.0
 Herc3 Hect domain and RLD 3 2.0
 Hmox1 Heme oxygenase (decycling) 1 −4.4
 Ifi204 Interferon-activated gene 204 −3.8
 Mmp3 Matrix metallopeptidase 3 −3.6
 Myc Myelocytomatosis oncogene −2.5
 Nr4a1 Nuclear receptor subfamily 4, group A, member 1 −5.3
 Pdia3 Protein disulfide isomerase-associated 3 −2.3
 Pnp Purine-nucleoside phosphorylase −2.7
 Sh3rf2 SH3 domain-containing ring finger 2 3.5
 Smtnl1 Smoothelin-like 1 2.7
 Stk17b Serine/threonine kinase 17b (apoptosis inducing) −2.5
 Tsc22d3 TSC22 domain family, member 3 −3.4
 Usp18 Ubiquitin-specific peptidase 18 −2.8
 Xaf1 X-Linked inhibitor of apoptosis (XIAP)-associated factor 1 −2.9
Drug metabolism
 Gsta3 Glutathione S-transferase, alpha 3 2.6
 Gstk1 Glutathione S-transferase kappa 1 2.1
 Mgst3 Microsomal glutathione S-transferase 3 2.1
Cytoskeleton
 Arpc3 Actin-related protein 2/3 complex, subunit 3 −2.1
 Cnn2 Calponin 2 −2.5
 Fhl3 Four and one-half LIM domains 3 2.6
 Msn Moesin −2.2
 Myo5c Myosin VC 2.2
 Myoz1 Myozenin 1 2.2
 Ptpn4 Protein tyrosine phosphatase, nonreceptor type 4 2.2
 Tagln2 Transgelin 2 −2.1
 Tpm4 Tropomyosin 4 −2.2
 Ttll7 Tubulin tyrosine ligase-like family, member 7 2.6
Cell adhesion
 Col15a1 Collagen, type XV, alpha 1 −2.5
 Cytip Cytohesin 1-interacting protein −2.6
 Lgals3bp Lectin, galactoside-binding, soluble, 3 binding protein −2.1
 Vcan Versican −2.6
Behavioral response to stimulus
 Amot Angiomotin 2.1
 Amot Angiomotin 2.3
 Sncg Synuclein, gamma 2.3
Cell migration and motility
 Bin2 Bridging integrator 2 −2.1
 Ctgf Connective tissue growth factor −2.3
 Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 −3.0
 Itga1 Integrin alpha 1 −2.7
 Itga6 Integrin alpha 6 −2.5
 Myh9 Myosin, heavy polypeptide 9, nonmuscle −2.3
 Nus1 Nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) −2.3
 Ret Ret proto-oncogene −2.7
 Rhob Ras homolog gene family, member B −2.0
 S1pr1 Sphingosine-1-phosphate receptor 1 −3.2
 Sema6c Sema domain, transmembrane domain (TM), and cytoplasmic domain (semaphorin), 6C 2.2
Alternative splicing
BC094916 cDNA sequence BC094916 −3.3
 Coq10b Coenzyme Q10 homolog B (S. cerevisiae) −2.9
 Far1 Fatty acyl CoA reductase 1 −2.1
 Htra3 HtrA serine peptidase 3 2.2
 Ifi203 Interferon-activated gene 203 −2.8
 Lgals9 Lectin, galactose-binding, soluble 9 −3.0
 Lpcat2 Lysophosphatidylcholine acyltransferase 2 −2.0
 Midn Midnolin −2.3
 Mgat4a Mannoside acetylglucosaminyltransferase 4, isoenzyme A −2.1
 Nnat Neuronatin 3.2
 Picalm Phosphatidylinositol-binding clathrin assembly protein −2.3
 Pla2g4e Phospholipase A2, group IVE 2.2
 Ptbp3 Polypyrimidine tract-binding protein 3 −2.2
 Rtp4 Receptor transporter protein 4 −2.5
 Sp100 Nuclear antigen Sp100 −2.5
 Trib1 Tribbles homolog 1 (Drosophila) −2.2
 Trp53inp2 Transformation-related protein 53-inducible nuclear protein 2 2.2
 Zbp1 Z-DNA-binding protein 1 −2.9
Transmembrane
 Abcb4 ATP-binding cassette, subfamily B (MDR/TAP), member 4 2.3
 Alox5ap Arachidonate 5-lipoxygenase activating protein −3.8
 Aqp4 Aquaporin 4 2.5
 B3galt2 UDP-Gal: βGlcNAc β 1,3-galactosyltransferase, polypeptide 2 2.6
 B4galt5 UDP-Gal: βGlcNAc β 1,4-galactosyltransferase, polypeptide 5 −4.6
 Bst2 Bone marrow stromal cell antigen 2 −5.3
 Cd53 CD53 antigen −2.7
 Chsy1 Chondroitin sulfate synthase 1 −2.2
 Cpt1b Carnitine palmitoyltransferase 1b, muscle 2.1
 Ctxn3 Cortexin 3 3.6
 Emp1 Epithelial membrane protein 1 −2.7
 Gpr65 G-Protein-coupled receptor 65 −2.4
 Gprc5a G-Protein-coupled receptor, family C, group 5, member A −2.1
 Has1 Hyaluronan synthase1 −2.2
 Ier3 Immediate early response 3 −2.7
 Ifitm3 Interferon-induced transmembrane protein 3 −2.3
 Mc5r Melanocortin 5 receptor 3.0
 Ms4a4b Membrane-spanning 4-domains, subfamily A, member 4B −2.3
 Ms4a4c Membrane-spanning 4-domains, subfamily A, member 4C −7.6
 Ms4a6b Membrane-spanning 4-domains, subfamily A, member 6B −2.6
 Ms4a6c Membrane-spanning 4-domains, subfamily A, member 6C −2.5
 Ms4a6d Membrane-spanning 4-domains, subfamily A, member 6D −3.5
 Slc2a4 Solute carrier family 2 (facilitated glucose transporter), member 4 3.0
 Slc7a8 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 −2.7
 Sptlc2 Serine palmitoyltransferase, long-chain base subunit 2 −2.1
 St3gal5 ST3 β-galactoside alpha-2,3-sialyltransferase 5 2.2
 Tecr Trans-2,3-enoyl-CoA reductase 2.1
 Tyrobp TYRO protein tyrosine kinase binding protein −2.1
Unknown or specific functions
 1810011O10Rik RIKEN cDNA 1810011O10 gene −2.2
 2310002L09Rik RIKEN cDNA 2310002L09 gene 2.3
 8430408G22Rik RIKEN cDNA 8430408G22 gene −7.3
 9430020K01Rik RIKEN cDNA 9430020K01 gene −2.1
 A730049H05Rik RIKEN cDNA A730049H05 gene −2.1
AA467197 Expressed sequence AA467197 −2.1
AI607873 Expressed sequence AI607873 −3.5
 Aldh1a7 Aldehyde dehydrogenase family 1, subfamily A7 2.9
 Apold1 Apolipoprotein L domain-containing 1 −9.8
 Arrdc2 Arrestin domain-containing 2 −2.5
 Cox7b2 Cytochrome c oxidase subunit VIIb2 −2.2
 Dcaf4 DDB1 and CUL4-associated factor 4 2.1
 Dennd4a DENN/MADD-containing 4A −2.3
 Dusp1 Dual-specificity phosphatase 1 −3.7
 Dusp10 Dual-specificity phosphatase 10 2.9
 Eif1a Eukaryotic translation initiation factor 1A −2.2
 Erdr1 Erythroid differentiation regulator 1 −10.0
 Exd2 Exonuclease 3–5 domain-containing 2 2.7
 Fam46a Family with sequence similarity 46, member A −2.0
 Fam101b Family with sequence similarity 101, member B −2.3
 Fcrls Fc receptor-like S, scavenger receptor −3.0
 Gbas Glioblastoma-amplified sequence 2.1
 Gm22 Predicted gene, 22 −2.2
 Gm4899 Predicted gene, 4899 −2.4
 Gm4955 Predicted gene, 4955 −3.4
 Gm6377 Predicted gene, 6377 −2.5
 Gm6904 Predicted gene, 6904 −2.1
 Gm10110 Predicted gene, 10110 2.2
 Gm10999 Predicted gene, 10999 2.0
 Gm11037 Predicted gene, 11037 −2.4
 Gm11710 Predicted gene, 11710 −2.0
 Gm11711 Predicted gene, 11711 −2.0
 Gm21742 Predicted gene, 21742 −9.7
 Gm21748 Predicted gene, 21748 −56.6
 Gm21750 Predicted gene, 21750 2.1
 Gm21857 Predicted gene, 21857 −4.2
 Gm21860 Predicted gene, 21860 −56.6
 Gm21887 Predicted gene, 21887 −9.3
 Gys1 Glycogen synthase 1, muscle 2.1
 Herc6 Hect domain and RLD 6 −2.6
 I830012O16Rik RIKEN cDNA I830012O16 gene −3.5
 Ifi44 Interferon-induced protein 44 −6.0
 Ifi202b Interferon-activated gene 202B −3.4
 Inmt Indolethylamine N-methyltransferase 2.9
 Kbtbd13 Kelch repeat and BTB (POZ) domain containing 13 2.1
 Klhdc3 Kelch domain-containing 3 2.2
 Klhl38 Kelch-like 38 2.6
 Lrrc14b Leucine-rich repeat containing 14B 2.2
 Lsmem2 Leucine-rich single-pass membrane protein 2 2.0
 Mettl7a1 Methyltransferase-like 7A1 2.4
 Mettl21e Methyltransferase-like 21E 6.6
 Mndal Myeloid nuclear differentiation antigen like −2.2
 Mup3 Major urinary protein 3 2.4
 Myom3 Myomesin family, member 3 2.3
 Odf3l2 Outer dense fiber of sperm tails 3-like 2 5.3
 Pde4b Phosphodiesterase 4B, cAMP specific −2.1
 Phf11b PHD finger protein 11B −3.1
 Phf11d PHD finger protein 11D −2.3
 Plac8 Placenta-specific 8 −2.5
 Pnp2 Purine-nucleoside phosphorylase 2 −2.7
 Ppp1r3c Protein phosphatase 1, regulatory (inhibitor) subunit 3C 3.0
 Prob1 Proline-rich basic protein 1 2.1
 Ptma Prothymosin alpha −2.4
 Pydc3 Pyrin domain-containing 3 −3.0
 Pydc4 Pyrin domain-containing 4 −3.3
 Retnlg Resistin-like gamma −5.7
 Rilpl1 Rab-interacting lysosomal protein-like 1 2.2
 Rragd Ras-related GTP-binding D 2.1
 Sbk2 SH3-binding domain kinase family, member 2 2.6
 Serpine1 Serine (or cysteine) peptidase inhibitor, clade E, member 1 −9.6
 Sh3pxd2b SH3 and PX domains 2B −2.0
 Slfn1 Schlafen 1 −3.2
 Slfn2 Schlafen 2 −3.7
 Slfn4 Schlafen 4 −9.7
 Slfn5 Schlafen 5 −2.3
 Slfn8 Schlafen 8 −2.7
 Tpm3-rs7 Tropomyosin 3, related sequence 7 −2.6
 Tra2a Transformer 2 alpha homolog (Drosophila) −2.5
 Trim30a Tripartite motif-containing 30A −3.9
 Trim30b Tripartite motif-containing 30B −3.6
 Trim30c Tripartite motif-containing 30C −3.4
 Trim30d Tripartite motif-containing 30D −3.8
 Wee1 WEE 1 homolog 1 (Schizosaccharomyces pombe) −2.1
 Xlr3b X-Linked lymphocyte-regulated 3B 2.4
 Xlr3c X-Linked lymphocyte-regulated 3C 2.2

This list excludes the gene-expression changes also conserved with either LS or EL treatment, listed in Table 2. Genes were functionally clustered using the Functional Annotation clustering tool from the Database for Annotation, Visualization and Integrated Discovery (DAVID). Positive fold changes indicate that gene expression was increased with treatment and vice versa.