Fig. 5.

List of differentially regulated core matrisome and matrisome-associated genes in DKO fibroblasts compared with WT. Differential gene expression in fibroblasts shows shift toward fibrillar ECM gene expression in DKO vs. WT muscle. This is accomplished by decreased expression of nonfibrillar ECM genes, increased expression of fibrillar ECM glycoproteins, increased expression of genes important in fibrillar ECM formation, decreased expression of Tgf-β antagonists, increased inhibition of collagen I breakdown, and increased expression of genes associated with ECM remodeling. Data are presented as log₂ fold change in DKO relative to WT fibroblasts.