Fig. 6.

List of differentially regulated core matrisome and matrisome-associated genes in DKO fibro/adipogenic progenitor cells compared with WT. Gene expression in FAPs demonstrated a shift to favor fibrillar ECM formation in cells from DKO muscle. This is demonstrated through increased expression of fibrillar ECM glycoproteins, increased expression of genes important in fibrillar ECM formation, decreased expression of a Tgf-β antagonist, increased inhibition of collagen I breakdown, and increased expression of genes associated with ECM remodeling. Data are presented as log₂ fold change in DKO relative to WT FAPs.