Table 2.
Five-year survival (%) and hazard ratios (HR) by level treatment at PTC and diagnostic group
| 5 year survival | Unadjusted | Adjusteda | |||||
|---|---|---|---|---|---|---|---|
| Diagnostic group | Level of treatment at PTC | % Survival | 95% CI | HR | 95%CI | HR | 95%CI |
| Leukaemia | All | 81 | (78, 84) | 1 | - | 1 | - |
| Some | 57 | (44, 68) | 2.34 | (1.54, 3.56) | 1.61 | (0.97, 2.67) | |
| None | 56 | (41, 69) | 2.66 | (1.68, 4.20) | 1.73 | (0.98, 3.04) | |
| Lymphoma | All | 89 | (85, 92) | 1 | - | 1 | - |
| Some | 84 | (74, 90) | 1.45 | (0.84, 2.51) | 1.51 | (0.78, 2.92) | |
| None | 89 | (82, 93) | 0.98 | (0.56, 1.70) | 1.12 | (0.54, 2.35) | |
| CNS tumours | All | 71 | (67, 75) | 1 | - | 1 | - |
| Some | 76 | (52, 89) | 0.6 | (0.25, 1.48) | 0.48 | (0.19, 1.20) | |
| None | 72 | (55, 84) | 0.98 | (0.54, 1.75) | 0.66 | (0.34, 1.29) | |
| Germ cell tumours | All | 91 | (85, 95) | 1 | - | 1 | - |
| Some | 94 | (88, 97) | 0.76 | (0.34, 1.70) | 1.24 | (0.42, 3.65) | |
| None | 95 | (88, 98) | 0.62 | (0.22, 1.17) | 1.83 | (0.50, 6.76) | |
| Soft tissue sarcomas | All | 54 | (45, 63) | 1 | - | 1 | - |
| Some & None | 75 | (59, 85) | 0.44 | (0.23, 0.83) | 0.48 | (0.23, 0.99) | |
| Bone tumours | All | 56 | (47, 64) | 1 | - | 1 | - |
| Some & None | 60 | (36, 78) | 0.98 | (0.49, 1.97) | 0.91 | (0.43, 1.88) | |
Footnote: aAdjusted models from multiple imputation models. Models adjusted for the following
Leukaemia – Diagnostic subgroup, white cell count, age, treatment, relapse, sex, diagnosis year, ethnicity and Townsend area deprivation
Lymphoma – Diagnostic subgroup, stage, age, treatment, relapse, sex, diagnosis year, ethnicity and Townsend area deprivation
CNS tumours – Diagnostic subgroup, grade, age, treatment, relapse, sex, diagnosis year, ethnicity and Townsend area deprivation
Germ cell tumours – Diagnostic subgroup, stage, age, relapse, sex, diagnosis year, ethnicity and Townsend area deprivation (not adjusted for treatment due to collinearity)
Soft tissue sarcomas – Diagnostic subgroup, age, treatment, relapse, sex, diagnosis year, ethnicity and Townsend area deprivation
Bone tumours – Diagnostic subgroup, primary site, age, treatment, relapse, sex, diagnosis year, ethnicity and Townsend area deprivation
Level of treatment at PTC “Some” ranges from 20% to 85% of all treatments received at PTC
Abbreviations: PTC = Principal Treatment Centre, HR = hazard ratio, CI = confidence interval, CNS = Central nervous system