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. 2017 Mar 4;12:24. doi: 10.1186/s13000-017-0613-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Algorithm for screening newly diagnosed colorectal carcinoma (CRC) for Lynch syndrome (LS). The initial step is to screen cases using immunohistochemistry (IHC) for mismatch repair proteins. When MLH1 and PMS2 are absent, the subsequent step is to utilize BRAF analysis by polymerase chain reaction (PCR) or immunohistochemistry