Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Mar 4;12:24. doi: 10.1186/s13000-017-0613-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 2 — Immunohistochemistry for mismatch repair proteins in a patient with sporadic hypermethylation of the MLH1 promoter. Hematoxylin & eosin (H&E) stain of the adenocarcinoma (a). Tumor cells show loss of MLH1 nuclear expression (b) and loss of PMS2 nuclear expression (c) while the stroma and lymphocytes shows strong intact staining. Conversely, tumor cells show intact nuclear expression of MSH2 (d) and MSH6 (e). This tumor showed BRAF V600E mutation by PCR consistent with sporadic microsatellite-unstable colorectal carcinoma