Table 2.

Comparison of the Amsterdam criteria, Amsterdam II criteria, and the revised Bethesda criteria

Amsterdam criteria (meet all sub criteria)	Amsterdam II criteria (meet all sub criteria)	Revised Bethesda criteria (meet one of the following sub criteria)
3 or more relatives with histologically confirmed colorectal cancer	3 or more relatives with Lynch syndrome-associated cancer (colorectal cancer or cancer of the endometrium, small intestine, ureter or renal pelvis); cancers are histologically verified	Colorectal cancer diagnosed in a patient aged <50 years
2 or more successive generations involved	2 or more successive generations affected	Presence of synchronous, metachronous colorectal cancer or other Lynch syndrome-related tumors: cancer of the colorectum, stomach, small intestine, pancreas, biliary tract, renal pelvis, ureter, ovary, brain; sebaceous gland adenoma or carcinoma and keratoacanthoma, regardless of age
1 or more of the cancers diagnosed before age 50 years	1 or more relatives diagnosed before the age of 50 years	Colorectal cancer with MSI phenotype, especially lymphocyte infiltration, diagnosed in a patient aged <60 years
One should be a first-degree relative of the other two	One should be a first-degree relative of the other two	Patient with colorectal cancer and a first-degree relative with a Lynch syndrome-related tumor, with one of these cancers diagnosed at age <50 years
Familial adenomatous polyposis should be excluded	Familial adenomatous polyposis should be excluded in cases of colorectal carcinoma	Patient with colorectal cancer with two or more first-degree or second-degree relatives with a Lynch syndrome-related tumor, regardless of age