Table 3.
P values for variants that were significantly associated after Benjamin Hochberg correction for multiple testing
| SNP | Control choice | Anatomical category (p values) | Phenotypic severity categories (p values) | |||||
|---|---|---|---|---|---|---|---|---|
| Insignificant | SVD | DVD | TVD | ANGINA | ACS | MI | ||
| rs17440396:G>A | Total Controls | 4.92 × 10−08 | 1.49 × 10−08 | 2.02 × 10−05 | 0.0001 | 1.43 × 10−06 | 1.04 × 10−11 | 6.79 × 10−06 |
| Cohort 1 | 2.36 × 10−06 | 2.13 × 10−06 | 0.0005 | 0.0027 | 2.54 × 10−05 | 4.78 × 10−09 | 0.0001 | |
| Cohort 2 | 1.77 × 10−06 | 2.47 × 10−06 | 0.0004 | 0.0021 | 2.18 × 10−05 | 1.55 × 10−08 | 0.0001 | |
| rs6589566:A>G | Total Controls | 0.0001 | 0.012 | 0.0008 | 2.61 × 10−05 | 1.26 × 10−07 | ||
| Cohort 1 | 0.017 | 0.044 | 0.004 | 0.0005 | ||||
| Cohort 2 | 0.036 | 4.70 × 10−06 | ||||||
| rs2849165:G>A | Total Controls | 0.001 | 0.001 | 0.0093 | 7.65 × 10−09 | 0.026 | ||
| Cohort 1 | 0.011 | 0.010 | 0.044 | 4.30 × 10−07 | ||||
| Cohort 2 | 0.015 | 0.016 | 0.020 | |||||
| rs10488699:G>A | Total Controls | 0.004 | ||||||
| Cohort 1 | 0.0007 | |||||||
| Cohort 2 | 0.018 | |||||||
| rs1263163:G>A | Total Controls | 7.83 × 10−06 | ||||||
| Cohort 1 | 0.0033 | |||||||
| Cohort 2 | 0.011 | |||||||
| rs633389:C>T | Total Controls | 0.014 | ||||||
| rs5081:A>T | Cohort 1 | 0.047 | ||||||
| rs633867:C>T | Cohort 1 | 0.047 | ||||||
| rs632153:G>T | Cohort 1 | 0.047 | ||||||
| rs1263171:G>A | Cohort 1 | 0.046 | ||||||
Blank cell—not significant, total control samples (n = 462), cohort 1—nondyslipidemic control cohort (n = 270), cohort 2—control cohort devoid of dyslipidemia, diabetes, and hypertension (n = 129)