Table 2.
Echocardiographic parameters of study groups at baseline
| Telmisartan group (n=39) | Amlodipine group (n=38) | Control group (n=33) | P | ||
|---|---|---|---|---|---|
| Left atrial size, cm | 3.4±0.2 | 3.5±0.2 | 3.4±0.2 | 0.251 | |
| LV end-diastolic dimension, cm | 4.3±0.3 | 4.3±0.5 | 4.6±0.4 | 0.0031 | |
| IST, cm | 1.1±0.1 | 1.1±0.1 | 0.8±0.1 | <0.0011 | |
| PWT, cm | 1.1±0.1 | 1.0±0.1 | 0.8±0.1 | <0.0011 | |
| LVEF, % | 60±3 | 60±2 | 64±4 | 0.252 | |
| E/A ratio | 1.0±0.3 | 0.9±0.2 | 0.9±0.3 | 0.289 | |
| IVRT, ms | 98±14 | 101±12 | 84±6 | <0.0011 | |
| Lat-sep e’, cm/s | 8.9±1.8 | 8.3±2.3 | 12.6±1.5 | <0.0011 | |
| Lateral IVRT, ms | 96±11 | 99±9 | 86±5 | <0.0011 | |
| Septal IVRT, ms | 95±9 | 100±12 | 85±7 | <0.0011 | |
| Lateral s’, cm/s | 11.5±0.6 | 11.1±0.8 | 12.7±0.5 | 0.189 | |
| Septal s’, cm/s | 10.9±0.6 | 10.8±0.7 | 11.5±0.6 | 0.354 | |
| E/e’ ratio | 7.8±1.5 | 8.6±2.2 | 5.2±0.9 | <0.0011 | |
| LAVI, mL/ m2 | 21.0±3.6 | 21.1±3.0 | 20.0±2.1 | 0.283 | |
| Lateral MPI | 0.64±0.16 | 0.64±0.11 | 0.41±0.05 | <0.0011 | |
| Septal MPI | 0.61±0.10 | 0.63±0.08 | 0.41±0.05 | <0.0011 | |
| LVMI, gr/ m2 | 114±23 | 112±24 | 97±13 | <0.0011 |
Values are expressed as mean±standard deviation. A - peak atrial filling velocity; E - peak early filling velocity; IST - interventricular septum thickness; IVRT - isovolumic relaxation time; Lat/sep e’ - mean of lateral and septal peak early diastolic velocities; LAVI - left atrial volume index; LV - left ventricle; LVEF - LV ejection fraction; LVMI - LV mass index; MPI - myocardial performance index; s’ - peak systolic annular velocity; PWT - Posterior wall thickness.
1
- Significant difference between control-amlodipine and control-telmisartan groups