Table 4.
Echocardiographic indices for the assessment of diastolic function before and after treatment
| Telmisartan group | Amlodipine group | ||||||
|---|---|---|---|---|---|---|---|
| Baseline | After treatment | P* | Baseline | After treatment | P* | P** | |
| E wave, cm/s | 68±12 | 67±11 | 0.326 | 68±14 | 66±13 | 0.344 | 0.795 |
| A wave, cm/s | 72±16 | 69±13 | 0.070 | 78±13 | 69±13 | <0.001 | 0.057 |
| MDT, ms | 226±25 | 221±16 | 0.122 | 227±20 | 222±25 | 0.217 | 0.922 |
| IVRT, ms | 98±14 | 89±10 | <0.001 | 101±12 | 91±10 | <0.001 | 0.773 |
| E/A ratio | 1.00±0.31 | 0.99±0.23 | 0.959 | 0.89±0.25 | 0.99±0.30 | 0.006 | 0.110 |
| Lat-sep e’, cm/s | 8.9±1.8 | 10.7±1.8 | <0.001 | 8.3±2.3 | 10.0±2.6 | <0.001 | 0.564 |
| Lateral IVRT, ms | 96±11 | 90±9 | <0.001 | 99±9 | 91±10 | <0.001 | 0.692 |
| Septal IVRT, ms | 95±9 | 88±7 | <0.001 | 100±12 | 90±7 | <0.001 | 0.785 |
| Lateral s’, cm/s | 11.5±0.5 | 11.8±0.6 | 0.286 | 11.1±0.8 | 11.6±0.7 | 0.156 | 0.324 |
| Septal s’, cm/s | 10.9±0.6 | 11.3±0.5 | 0.212 | 10.8±0.7 | 11.1±0.7 | 0.243 | 0.355 |
| E/e’ ratio | 7.8±1.5 | 6.3±1.1 | <0.001 | 8.6±2.2 | 6.9±1.9 | <0.001 | 0.516 |
| LAVI, mL/m2 | 21.0±3.6 | 18.9±2.7 | <0.001 | 21.1±3.0 | 19.0±2.7 | <0.001 | 0.959 |
| Lateral MPI | 0.64±0.16 | 0.61±0.23 | 0.021 | 0.64±0.11 | 0.58±0.07 | <0.001 | 0.270 |
| Septal MPI | 0.61±0.10 | 0.58±0.08 | 0.006 | 0.63±0.08 | 0.59±0.07 | <0.001 | 0.837 |
Values are expressed as mean±standard deviation. E wave and A wave-peak early filling (E) and atrial filling (A) velocities; IVRT-isovolumic relaxation time; Lat/sep e’-mean of lateral and septal peak early diastolic velocities; LAVI-left atrial volume index; MDT-deceleration time of peak E wave; MPI-myocardial performance index; s’-peak systolic annular velocity.
*
P value of paired samples test;
**
P value of comparison of groups in terms of after treatment values corrected for baseline values