Table 3.

Clinical and biochemical parameters according to MTHFR C677T genotypes in T2DM patients

	MTHFR genotype
Parameters	CC (n=31)	CT+TT (n=76)	P
cIMT, μm	71.70 (40.00-120.00)	73.30 (40.00-290.00)	0.459
Gender, male/female	12 / 19	27 / 49	0.756
Age, years	62.56±11.84	61.98±11.47	0.319
Diabetes duration, years	2.50 (0.00-35.00)	5.50 (0.00-30.00)	0.384
BMI, kg/m2	32.17±7.96	32.41±5.81	0.882
Total cholesterol, mg/dL	183.06±33.56	185.53±43.28	0.778
HDL-cholesterol, mg/dL	43.00 (18.00-77.00)	40.50 (22.00-107.00)	0.079
LDL-cholesterol, mg/dL	101.00 (57.00-155.60)	96.50 (55.00-269.00)	0.685
Triglyceride, mg/dL	137.00(48.00-580.00)	182.0 (60.00-821.00)	0.058
Fasting plasma glucose, mg/dL	128.00 (76.00-340.00)	131.00 (63.00-450.00)	0.542
Hct, %	38.96±4.18	38.86±4.29	0.108
SBP, mm Hg	148.17±25.34	148.62±21.02	0.931
DBP, mm Hg	86.17±11.94	87.04±14.05	0.749
hsCRP, mg/L	1.28 (0.14-30.60)	1.20 (0.19-68.90)	0.939
Serum iron, μg/dL	77.0 (26.00-168.00)	76.00 (19.00-149.00)	0.635
Folate, ng/mL	8.47 (3.74-19.30)	8.08 (3.50-17.50)	0.668
Hcy, μmol/L	14.48±3.29	14.64±3.06	0.872
Vitamin B12, pg/mL	238.00 (150.00-507.00)	250.50 (151.00-845.00)	0.814
MCV, fL	83.25±5.00	82.96±5.21	0.792
HgB, g/dL	12.99±1.36	12.90±1.68	0.765
Hct, %	38.96±4.18	38.86±4.29	0.977
HbA1C, %	7.80±1.40	8.10±1.50	0. 691
HOMO S, %	2.99 (0.59-9.25)	3.67 (0.53-9.17)	0.559
Visceral fat area, cm2	12.00 (3.00-25.00)	12.00 (5.00-23.00)	0.985

The results are shown as mean±SD (Standard deviation) and median (min-max).

BMI - body mass index; cIMT - carotid intimal-medial thickness; DBP - diastolic blood pressure; Hct - hematocrit; Hcy - homocysteine; HDL - high-density lipoprotein;

Hb - hemoglobin; hs-CRP - high-sensitivity C-reactive protein; HOMO S - Homeostasis Model Assessment for Insulin Sensitivity; HbA1c - glycosylated hemoglobin; LDL - low-density lipoprotein; MCV - mean corpuscular volume; N - number of individuals; SBP - systolic blood pressure; T2DM - type 2 diabetes mellitus