Table 4. Univariate and multivariate analysis of associations between Ki-67 score and standard variables and cancer-specific survival in 179 women with endometrial cancer.
| Variable |
Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age (1 year) | 1.10 | 1.05–1.15 | <0.0001**** | 1.06 | 1.001–1.13 | 0.028* |
| Body mass index | ||||||
| <30 kg/m2 | 1.00 | — | 0.52 | — | — | — |
| ≥30 kg/m2 | 1.51 | 0.43–5.25 | ||||
| Grade | ||||||
| 1 | 1.00 | — | 0.014** | — | — | — |
| 2 | 0.584 | 0.05–6.44 | ||||
| 3 | 4.975 | 1.17–21.12 | ||||
| Stage | ||||||
| 1 | 1.00 | — | <0.0001**** | 1.00 | — | 0.004** |
| 2 | 0.96 | 0.12–7.99 | 3.27 | 0.34–31.78 | ||
| 3 | 7.8 | 3.03–20.11 | 6.44 | 2.07–20.06 | ||
| 4 | 23.36 | 6.49–84.05 | 16.09 | 2.83–91.36 | ||
| Histological type | ||||||
| Endometrioid | 1.00 | — | <0.0001**** | 1.00 | — | 0.002** |
| Non-endometrioid | 8.16 | 3.27–20.39 | 5.72 | 1.93–16.95 | ||
| Lymphovascular space invasion | ||||||
| Absent | 1.00 | — | ||||
| Present | 4.54 | 2.21–9.33 | <0.0001**** | — | — | — |
| Depth of myometrial invasion | ||||||
| <50% | 1.00 | — | — | — | — | |
| ≥50% | 2.46 | 1.03–5.90 | 0.043* | |||
| Any adjuvant therapy | ||||||
| No | 1.00 | — | 0.202 | — | — | — |
| Yes | 2.05 | 0.68–6.19 | ||||
| Ki-67 score (10% increase) | 1.31 | 1.07–1.60 | 0.010** | 1.14 | 0.91–1.41 | 0.257 |
Abbreviations: CI, confidence interval; HR, hazard ratio.
Ki-67 was no longer statistically significantly associated with cancer-specific survival when included in the multivariate analysis.
Variables found to be statistically significantly associated with cancer-specific survival in the univariate analysis (P≤0.05) were included in the multivariate analysis; ‘—' represents not statistically significant in the multivariate analysis. *p≤0.05, **p≤0.01, ***p≤0.001, ****p≤0.0001.