Cumulative event rate of clinical diagnosis for cohort members according to their age, estimated as a function of their age rather than time after blood draw. A. Individuals are grouped according to serology result after those with equivocal serology were excluded. The cumulative rate of celiac disease diagnosis across age was markedly higher in seropositive persons (p<.001), in whom median age at celiac disease diagnosis was 53.1 years. B. All individuals in the cohort are included and grouped according to tTGA <4 4–10, or ≥10 U/mL, event rates across age were higher for increasing tTGA levels (p<.001), with median age at celiac disease diagnosis of 49.7 years for individuals with tTGA ≥10 U/mL. tTGA=Tissue transglutaminase immunoglobulin A