Skip to main content
. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: J Mol Cell Cardiol. 2017 Jan 25;104:9–16. doi: 10.1016/j.yjmcc.2017.01.015

Figure 3. Effect of cAMP on SR Ca2+ load and leak.

Figure 3

A, changes of [Ca2+]SR after SERCA inhibition with thapsigargin (TG). Application of caffeine at the end of experiment indicates complete Ca2+ depletion of the SR. B, changes of [Ca2+]SR during cAMP application (black circles) and during cAMP applications in the presence of PKI (grey circles). In both cases, thapsigargin (TG) was applied to inhibit SERCA. The dashed curves show fit of [Ca2+]SR decay during SERCA inhibition. C, time constant (τ) of [Ca2+]SR decay during SERCA inhibition in control conditions, during cAMP application and during cAMP applications in the presence of PKI.