. 2016 Nov 7;43(3):401–410. doi: 10.1007/s11239-016-1449-x

Table 6.

Gene–gene interactive effects of homocysteine related SNPs on CIMT indexes

SNP	Model	CCA-IMT	Bif-IMT	CIMT
SNP1: CBS rs2851391 × SNP2: BHMT rs10037045	Index changes if risk allele of SNP1 exists^a	0.051	0.042	0.043
	Index changes if risk allele of SNP2 exists^b	−0.023	−0.003	−0.013
	Index changes if risk alleles of both SNPs coexist^c	0.080	0.061	0.075
	p for interaction	0.011^{^}	0.402	0.052
SNP1: CBS rs2851391 × SNP2:MTR rs1805087	Index changes if risk allele of SNP1 exists^a	0.042	0.039	0.035
	Index changes if risk allele of SNP2 exists^b	−0.021	−0.011	−0.020
	Index changes if risk alleles of both SNPs coexist^c	0.101	0.073	0.089
	p for interaction	0.007^{^^}	0.227	0.022^{^}

Adjusting for age, sex, smoking, BMI, diabetes, SBP, TG, LDL-C

^aCoefficient for SNP1 in full mixed model

^bCoefficient for SNP2 in full mixed model

^cSum of coefficients for SNP1, SNP2 and interaction term in full mixed model

^{^} p < 0.05, ^{^^} p < 0.01