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. 2017 Feb 16;2017:2613198. doi: 10.1155/2017/2613198

Figure 5.

Figure 5

Inhibitory effect of JPJD on the metastasis of CRC cells in nude mice. (a, b) LoVo cells were used to establish the model of orthotopic transplantation tumor. After two weeks, the mice were randomized into four groups of 8 animals each. JPJDs with different doses were intragastrically administrated every day for the above four groups. After 28 days, the nude mice were sacrificed. The primary tumors were photographed and determined for tumor weights. (c) HE staining was applied to detect the liver and lung metastases in tumor-bearing mice, and the numbers of metastatic lesions in each group were determined. (d) Effect of JPJD on the survival time of tumor-bearing mice. (e) Effect of JPJD on the life extended rate of tumor-bearing mice. Here, JPJD-L is JPJD low-dose (250 mg/kg/day), JPJD-M is JPJD middle-dose (500 mg/kg/day), and JPJD-H is JPJD high-dose (1000 mg/kg/day). ∗P < 0.05 and ∗∗P < 0.01, versus control mice; #P < 0.05  ##P < 0.01, versus JPJD-L group.