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JPJD inhibited the EMT in vivo through TGF-β/Smad signaling pathway. Western blot was performed to detect the effect of JPJD on the process of EMT, as well as the levels of p-Smad2/3, Smad2/3, and Snail in the orthotopic CRC tumor tissues. Here, JPJD-L is 250 mg/kg/day, JPJD-M is 500 mg/kg/day, and JPJD-H is 1000 mg/kg/day. ∗P < 0.05 and ∗∗P < 0.01, versus LoVo cells without JPJD treatment.
