Table 2.
Transcript relationships with PD-BS and osteoprogenitor indicators.
| Gene | Correlation with PD-BS (rho = (p)) | Gradient |
Range (min–max) |
Also related to PD? | Relationship with CFU-O? | Relationship with Ca++? |
|---|---|---|---|---|---|---|
| Higher expression closer to senescence | ||||||
| ACVR2A | −0.454∗∗ | −0.0727 | 0.07–3.41 | Y | Y | Y |
| ALPL | −0.348∗ | −0.1095 | 0.03–5.26 | Y | Y | |
| ANGPTL4 | −0.422∗ | −0.0336 | 0.01–1.57 | Y | Y | |
| BAMBI | −0.454∗∗ | −0.2279 | 0.29–8.67 | Y | Y | Y |
| BMPER | −0.686∗∗ | −0.0985 | 0.06–9.28 | Y | Y | Y |
| COL1A1 | −0.551∗∗ | −7.2721 | 6.35–302 | Y | Y | Y |
| COL1A2 | −0.340∗ | −10.771 | 14.6–632 | |||
| FGFR1 | −0.453∗∗ | −0.2315 | 0.61–13.6 | Y | Y | |
| FZD4 | −0.477∗∗ | −0.0789 | 0.07–12.2 | Y | Y | |
| IGFBP3 | −0.417∗ | −5.1189 | 8.78–236 | Y | Y | |
| JAG1 | −0.465∗∗ | −0.1876 | 0.25–27.0 | Y | ||
| SFRP4 | −0.511∗∗ | −0.1091 | 0.004–35.4 | Y | Y | Y |
| SORT1 | −0.331∗ | −0.1515 | 0.134–5.68 | Y | Y | |
| #SPARC | −0.753∗ | −16.614 | 33.2–545 | Y | Y | Y |
| TNFRSF11B | −0.642∗∗ | −0.7225 | 0.179–29.2 | Y | Y | Y |
| Lower expression closer to senescence | ||||||
| CEBPA | 0.358∗ | 0.0012 | 0.001–0.119 | Y | ||
| SFRP1 | 0.369∗ | 0.0034 | 0.002–0.634 | Y | ||
| SOX2 | 0.390∗ | 0.3751 | 0.005–22.9 | Y |
∗ p < 0.05; ∗∗p < 0.01; Y (yes) = p < 0.05; empty = no significance. #Strongest candidate for prediction model based on multiple correlations and steepest gradient.