Table 2.
Serum circulating levels of cytokines in patients with AILD and in healthy controls. Numbers are presented as median (range).
| IL-2, pg/mL | IL-4, pg/mL | IL-6, pg/mL | IL-8, pg/mL | IL-10, pg/mL | IFN-γ, IU/mL | TNF-α, pg/mL | |
|---|---|---|---|---|---|---|---|
| AILD (n = 60) | 2.07 (0.11–111.87)a | 0.18 (0.11–1.25) | 0.70 (0.17–99.86)b | 1.66 (0.45–34.58)b | 0.57 (0.11–951.96) | 4.77 (0.59–493.96) | 2.61 (0.23–120.88)b |
| AIH (n = 32) | 2.33 (0.19–41.33) | 0.18 (0.11–0.34) | 1.14 (0.20–19.4)b | 1.50 (0.45–34.58)a | 0.62 (0.22–29.94) | 4.60 (0.59–133.32) | 2.38 (0.56–52.96)a |
| Overlap syndrome (n = 28) | 1.97 (0.11–111.87)a | 0.18 (0.12–1.25) | 0.60 (0.17–99.86)a | 2.15 (0.60–27.60)b | 0.52 (0.11–951.96) | 5.12 (1.54–493.96) | 2.66 (0.23–120.88)b |
| Control (n = 21) | 2.76 (0.45–4.10) | 0.17 (0.11–0.53) | 0.40 (0.14–2.65) | 0.53 (0.35–2.38) | 0.42 (0.13–51.67) | 5.65 (0.59–26.22) | 1.65 (0.21–7.54) |
AILD: autoimmune liver disease; AIH: autoimmune hepatitis; IL: interleukin; IFN-γ: interferon-gamma; TNF-α: tumour necrosis factor-alpha.
a p < 0.05 compared with healthy controls group (Mann–Whitney U test);
b p < 0.01 compared with healthy controls group (Mann–Whitney U test).