Table 1.
Characteristics of the studies included in the meta-analysis.
| Study ID (first author, year) | Classification of GERD | Type of syndrome | Sample size | Age (years) | Course of disease | Duration | Intervention | Outcome measures | ||
|---|---|---|---|---|---|---|---|---|---|---|
| EG (M/F) | CG (M/F) | EG | CG | |||||||
| He and Han 2016 [29] | NERD | Stagnated heat in liver and stomach syndrome | 45 (26/19) | 45 (29/16) | 21–68 | 2 days–102 days | 8 weeks | Modified Banxia Xiexin decoction, 100 mL, b.i.d |
PPIs | ①④⑤ |
| Shou 2015 [30] | N/A | N/A | 43 (24/19) | 43 (23/20) | E: 51.7 ± 12.9 C: 52.6 ± 12.9 |
1 year–10 years | 60 d | Banxia Xiexin decoction, 100 mL, t.i.d |
PPIs + 5-HT4RA | ①⑥ |
| Yang et al. 2015 [31] | RE | N/A | 70 (38/32) | 69 (35/34) | E: 41.89 ± 5.67 C: 40.31 ± 6.98 |
E: 4.56 ± 1.23 C: 4.09 ± 1.68 |
3 months | Modified Banxia Xiexin decoction plus Sini Powder, b.i.d |
PPIs + D2RA | ②③⑥ |
| Wang et al. 2013 [32] | N/A | Cold and heat mixed type | 56 (30/26) | 56 (32/24) | 22–64 | 1 year–12 years | 8 weeks | Modified Banxia Xiexin decoction, b.i.d + point injection (vitamin B6), q.o.d |
PPIs + D2RA | ①②⑦ |
| Chen 2013 [33] | N/A | Stagnation of liver and stomach Qi, stomachache due to cold, deficiency of stomach, yin, hyperactivity of stomach, heat, syndrome of retention of food in stomach | E:C 58/58 M:F 70/46 |
21–68 | 0.5 year–13 years | 4 weeks | Modified Banxia Xiexin decoction, b.i.d |
PPIs + 5-HT4RA | ①⑥ | |
| Sun et al. 2013 [34] | N/A | N/A | 30 (17/13) | 30 (14/16) | 21–61 | 1 year–6 years | 30 d | Modified Banxia Xiexin decoction |
PPIs + D2RA | ①②⑥⑧ |
| Cao 2013 [35] | RE | N/A | 32 (26/6) | 32 (22/10) | Mentioned | N/A | 8 weeks | Modified Banxia Xiexin decoction, 1 dose/d |
D2RA + H2RA | ①②⑥ |
| Zhu et al. 2012 [36] | RE | N/A | 60 (32/28) | 60 (29/31) | 19–72 | 3 months–12 years | 4 weeks | Banxia Xiexin decoction plus Xuanfu Daizhe decoction, 250 mL, b.i.d | PPIs | ①⑥ |
| Shen 2012 [37] | RE | Cold and heat mixed type | 43 (27/16) | 40 (26/14) | 26–70 | N/A | 56 days | Modified Banxia Xiexin decoction, 100 mL, b.i.d | PPIs + D2RA | ①⑨ |
| Lu et al. 2010 [38] | RE | Stomach Qi rising | 39 (20/19) | 39 (19/20) | 20–65 | 1–6 years | 4 weeks | Modified Banxia Xiexin decoction, b.i.d | PPIs + 5-HT4RA | ①②⑥ |
| Chen et al. 2009 [39] | RE | N/A | 90 (56/34) | 60 (39/21) | 18–69 | 2–10 weeks | 8 months | Modified Banxia Xiexin decoction, 150 mL, b.i.d | PPIs | ①②③⑥⑨ |
| Huang and Wu 2007 [40] | RE | N/A | 60 (35/25) | 60 (38/22) | 18–61 | 2 months–30 years | 8 weeks | Modified Banxia Xiexin decoction, b.i.d | PPIs + 5-HT4RA | ① |
①: overall clinical efficacy; ②: efficacy under gastroscope; ③: recurrence rate; ④: RDQ, SAS, and SDS grading; ⑤: SF-36 dimensions of grading; ⑥: symptom integrals; ⑦: plasma GAS level; ⑧: pathological effect; ⑨: RE classification in gastroscopy; GERD: gastroesophageal reflux disease; NERD: nonerosive reflux disease; RE: reflux esophagitis; M: male; F: female; EG: experiment group; CG: control group; N/A: not applicable; RDQ: reflux disease diagnostic questionnaire; SAS: self-rating anxiety scale; SDS: self-rating depression scale; PPIs: proton pump inhibitors; 5-HT4RA: 5-HT4 receptor agonists; D2RA: D2 receptor antagonists; H2RA: H2 receptor antagonists.