Table 2.1.
Univariate analysis of predictors of progression-free survival (time from definitive surgery)
| No event |
Event |
|||||
|---|---|---|---|---|---|---|
| Characteristics | No. | % | No. | % | HR (95% CI) | P-value |
| Total patients | 110 | 66 | 56 | 34 | ||
| Age (continuous) | 1.00 (0.97, 1.02) | 0.6306 | ||||
| Age group | ||||||
| <50 years | 46 | 61 | 30 | 39 | 1 | - |
| 50+ years | 64 | 71 | 26 | 29 | 0.75 (0.44, 1.28) | 0.2911 |
| LVI | ||||||
| No | 75 | 82 | 17 | 18 | 1 | - |
| Yes | 35 | 47 | 39 | 53 | 3.37 (1.87, 6.06) | <0.0001* |
| Subtype | 0.0352* | |||||
| Hormone positive/HER2 | 51 | 71 | 21 | 29 | 1 | - |
| HER2 positive | 43 | 74 | 15 | 26 | 0.89 (0.45-1.77) | 0.7481 |
| TNBC | 16 | 44 | 20 | 56 | 2.00 (1.06-3.75) | 0.0314* |
| Post-surgical stage and nodal | 0.0610 | |||||
| pCR | 29 | 85 | 5 | 15 | 1 | - |
| T+, N negative | 29 | 76 | 9 | 24 | 1.76 (0.59, 5.26) | 0.3119 |
| N+, regardless of T | 52 | 55 | 42 | 45 | 2.80 (1.10, 7.11) | 0.0303* |
| Size (continuous) | 1.05 (0.92, 1.20) | 0.4745 | ||||
| Size | ||||||
| 0-5 cm | 83 | 64 | 46 | 36 | 1 | - |
| >5 cm | 27 | 77 | 8 | 23 | 0.74 (0.35, 1.57) | 0.4369 |
| Grade | ||||||
| low | 41 | 76 | 13 | 24 | 1 | - |
| High | 66 | 61 | 42 | 39 | 1.79 (0.96, 3.35) | 0.0682 |
Abbreviations: HR, Hazard ratio; CI, confidence interval; LVI: lymphovascular invasion; pCR: pathologic response; TNBC: Triple Negative Breast Cancer