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. 2017 Mar 6;8:103. doi: 10.3389/fimmu.2017.00103

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Copyright © 2017 Duurland, Brown, O’Shaughnessy and Wedderburn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD161⁺ conventional T cells (Tconv) and CD161⁺ regulatory T cells (Treg) from the inflamed site show lower expression of gut-homing receptors. (A,B) Representative plots and summary graphs showing percentage CCR9⁺ and integrin α4⁺β7⁺ cells within CD161⁻ (○) and CD161⁺ () Tconv (A) and Treg (B) in juvenile idiopathic arthritis (JIA) peripheral blood (PB) (n = 10) and JIA synovial fluid (SF) (n = 18). (C,D) Synovial fluid mononuclear cells (SFMC) were cultured in presence of ATRA as described before (n = 3). (C) Representative plots and summary graphs showing percentage CCR9⁺ and integrin α4⁺β7⁺ cells within CD161⁻ (○) and CD161⁺ () CD3⁺CD4⁺ T cells at culture conditions indicated. (D) Percentage CD161⁺ cells within CD3⁺CD4⁺ T cells at end of culture. Statistical significance: *P < 0.05, **P < 0.01, ***P < 0.001.

Inline graphic — CD161⁺ conventional T cells (Tconv) and CD161⁺ regulatory T cells (Treg) from the inflamed site show lower expression of gut-homing receptors. (A,B) Representative plots and summary graphs showing percentage CCR9⁺ and integrin α4⁺β7⁺ cells within CD161⁻ (○) and CD161⁺ () Tconv (A) and Treg (B) in juvenile idiopathic arthritis (JIA) peripheral blood (PB) (n = 10) and JIA synovial fluid (SF) (n = 18). (C,D) Synovial fluid mononuclear cells (SFMC) were cultured in presence of ATRA as described before (n = 3). (C) Representative plots and summary graphs showing percentage CCR9⁺ and integrin α4⁺β7⁺ cells within CD161⁻ (○) and CD161⁺ () CD3⁺CD4⁺ T cells at culture conditions indicated. (D) Percentage CD161⁺ cells within CD3⁺CD4⁺ T cells at end of culture. Statistical significance: *P < 0.05, **P < 0.01, ***P < 0.001.