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. 2017 Mar 6;8:103. doi: 10.3389/fimmu.2017.00103

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Copyright © 2017 Duurland, Brown, O’Shaughnessy and Wedderburn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD161⁺ and CD161⁻ conventional T cells (Tconv) and regulatory T cells (Treg) from the inflamed site show sharing of TCRβ repertoires. Purified CD161⁺ and CD161⁻ Tconv and Treg from juvenile idiopathic arthritis (JIA) synovial fluid (SF) (n = 2) and CD161⁺ and CD161⁻ Tconv from JIA peripheral blood (PB) (n = 1) were analyzed for TCRβ repertoire. Sample JIA PB/SF 1 is a paired sample whereas JIA SF 2 is not. (A) Pair-wise comparison plots showing average productive frequency of shared (purple) and unique clones (on x- or y-axis) between the different cell populations from JIA SF as indicated. (B) Venn diagrams showing number of shared and unique TCR sequences between the cell populations from JIA PB/SF as indicated. Frequencies indicate percentage of unique sequences shared between the two repertoires divided by total sequences for that cell population. (C) Summary graphs depicting repertoire overlap (calculated as followed: shared sequences by samples A and B divided by total sequences in samples A and B) between indicated cell populations from JIA SF only (left, n = 2), and CD161⁻ and CD161⁺ Tconv from paired JIA PB/SF 1 (right, n = 1). (D) Summary graphs for clonality and entropy (Shannon entropy) for cell populations from JIA SF (black bars, n = 2) and JIA PB (gray bars, n = 1).