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. 2017 Mar 6;8:343. doi: 10.3389/fmicb.2017.00343

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Copyright © 2017 de la Cruz, González, Parish, Onishi, Tormo, Martín, Peláez, Zink, El Aouad, Reyes, Genilloud and Vicente.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LiaRS—Lipid II cycle interfering antibiotic response Regulator and Sensor: Two-component antibiotic sensing system in Bacillus subtilis that co-ordinates genetic response to inhibitors of peptidoglycan synthesis that interfere with the lipid II cycle. Background strain: Bacillus subtilis CU1065; HB0950: lacZ fusion; HB0953: lacZ fusion, kanR insertion (liaR gene disrupted). LiaRS autoregulates the liaIHGFSR operon. Induction of the liaIH operon mediated by the two-component liaRS sensor/regulator system. Specificity associated with liaRS. lacZ inserted downstream from P_liaI. Induction results in production of β-galactosidase. Induction of β-galactosidase in B. subtilis HB0953 indicates that induction was not due to an inhibitor of peptidoglycan synthesis.