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. 2017 Feb 27;6(2):e299. doi: 10.1038/oncsis.2017.4

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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FASN inhibition significantly enhances E₂-dependent ERα transcriptional activity in MCF-7/HER2-18, BT-474 and MCF-7/HRG cells. BT-474 (left), MCF-7/HER2-18 (middle), and MCF-7/HRG (right) cells were transiently co-transfected with an ERE-luciferase reporter and pRL/CMV. Transfected cells were incubated for 24 h with vehicle (control), E₂, ICI 182 780, C75 or U0126, individually or in combination as indicated. Cell extracts were assayed for luciferase activity and the data represent mean±s.d. (n=4). Non-significant (NS) differences (P>0.05) were identified by ANOVA followed by Scheffé's multiple contrasts; *P<0.05 compared with control cells (in medium supplemented with 10⁻⁹ mol/l E₂) by ANOVA followed by Scheffé's multiple contrasts.