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. 2017 Feb 22;7(2):e013879. doi: 10.1136/bmjopen-2016-013879

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Overview of the exposure chamber procedure and sampling of blood. During the precondition, participants were seated in the exposure chamber with the door open. The door was thereafter closed, and the chamber session began at minute 0. During the first 10 min of testing, no odorant was delivered into the chamber, after which n-butanol was released into the chamber and reached a peak concentration after about 8 min. The concentration remained at this peak level (3.7 ppm) for the remaining part of the exposure session. Venous blood samples was collected within 30 min prior to the exposure session (TP1), within 15 min postexposure session (TP2) and again 4 hours after the exposure session was terminated (TP3). TP, time point.