Table 3.

AUC values for each gene

	MCS group		Control group
Genes	Mean AUC	±SD	Mean AUC	±SD	p Values*	Adjusted p values†
IL-1β	1.352	0.705	1.050	0.649	0.235	1.0
IL-6	0.018	0.009	0.012	0.006	0.030	0.45
IL-8	1.133	0.687	1.316	0.671	0.343	1.0
IL-10	0.025	0.036	0.009	0.004	0.074	1.0
TNFα	0.302	0.189	0.260	0.085	0.494	1.0
NFKB1	0.865	0.321	0.714	0.160	0.105	1.0
P2RX4	0.455	0.217	0.374	0.104	0.206	1.0
P2RX5	0.597	0.217	0.584	0.290	0.794	1.0
TRPV1	0.102	0.031	0.095	0.036	0.593	1.0
TRPV4	0.016	0.019	0.008	0.005	0.129	1.0
TRPA1	0.010	0.006	0.008	0.005	0.385	1.0
ADRB2	1.022	0.332	1.006	0.330	0.781	1.0
COMT	0.369	0.181	0.311	0.079	0.259	1.0
CAT	6.314	2.154	6.527	2.619	0.900	1.0
ASAH1	11.904	4.297	9.657	2.561	0.092	1.0
SPHK1	0.101	0.066	0.080	0.030	0.269	1.0
SGPL1	0.598	0.171	0.544	0.136	0.350	1.0

*p Values calculated for each gene using Student's t-test.

†pValues after Holm-Bonferroni correction for multiple testing.

Values have been estimated using trapezoidal integration covering the 5-hour time span between initial and the last blood sample. AUC values are presented as group means with SD.

ADRB2, adrenergic β-2 receptor; ASAH1, N-acylsphingosine amidohydrolase (acid ceramidase) 1; AUC, area under the curve; CAT, catalase; COMT, catechol-O-methyltransferase; IL, interleukin; MCS, multiple chemical sensitivity; NFKB1, nuclear factor of κ light polypeptide gene enhancer in B cells 1; P2RX4, purinergic receptor P2X, ligand-gated ion channel, 4; P2RX5, purinergic receptor P2X, ligand-gated ion channel, 5; SGPL1, sphingosine-1-phosphate lyase 1; SPHK1, sphingosine kinase 1; TNF, tumour necrosis factor; TRPA1, transient receptor potential cation channel, subfamily A, member 1; TRPV1, transient receptor potential cation channel, subfamily V, member 1; TRPV4, transient receptor potential cation channel, subfamily V, member 4.