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Signaling pathways of the major platelet receptors for adhesive ligands leading to integrin αIIbβ3 activation and important roles of ITAM pathway
sGC, soluble guanylyl cyclase; NOS, NO synthase; SFK, src family kinase; LEC, lymphatic endothelial cell; SLP-76, SH2 domain-containing leukocyte phosphoprotein of 76 kDa; Btk, Bruton's tyrosine kinase; Rap1b, RAS-related protein 1b; MAPKs, mitogen-activated protein kinases; TXA2, thromboxane A2.
