Table 2.

Amino acid residues of the ligand‐binding sites of hRXRs and hRARs

hRXRα	hRXRβ	hRXRγ	hRARα	hRARβ	hRARγ
			F199	F199	F201
I268	I339	I269	F228	F228	F230
A271	A342	A272	L231	L231	L233
A272	A343	A273	S232	A232	A234
Q275	Q346	Q276	C235	C235	C237
N306	N377	N307	L266	L266	L268
L309	L380	L310	L269	L269	L271
I310	I381	I311	I270	I270	M272
S312	S383	S313	R272	R272	R274
F313	F384	F314	I273	I273	I275
R316	R387	R317	R276	R276	R278
L326	L397	L327	F286	F286	F288
A327	A398	A328	S287	S287	S289
V342	V413	V343	F302	F302	F304
I345	I416	I346	L305	L305	L307
C432	C503	C433	G391	G391	G393
H435	H506	H436	R394	R394	R396
L436	L507	L437	V395	V395	A397
F439	F510	F440	L398	L398	L400
			M413	M413	M415
			L414	L414	L416

Residues that differ between the subtypes are represented in bold face. The sequence alignments of hRXR and hRAR LBDs have been reported in Ref. 1.