Table 2.
TATA‐containing and TATA‐less promoters are distinctly different in their structural properties
| Average free energy | DNase 1 sensitivity | Nucleosome positioning preference | Curvature | |
|---|---|---|---|---|
| S. cerevisiae | 9.8373 × 10−14 | 1.1455 × 10−30 | 1.1788 × 10−05 | 9.5 × 10−03 |
| C. elegans | 1.2755 × 10−26 | 1.7171 × 10−47 | 1.0664 × 10−06 | 1.8608 × 10−11 |
| D. melanogaster | 6.7109 × 10−62 | 1.8661 × 10−54 | 1.0513 × 10−57 | 3.0452 × 10−66 |
| Zebrafish | 4.2503 × 10−11 | 1.0092 × 10−09 | 9.4065 × 10−09 | 1.0664 × 10−06 |
| Mouse | 1.7325 × 10−64 | 1.9847 × 10−06 | 1.8379 × 10−18 | 5.0682 × 10−68 |
| Human | 5.0682 × 10−68 | 2.8143 × 10−45 | 5.0682 × 10−68 | 5.0682 × 10−68 |
Two‐sample Kolmogorov–Smirnov test (KS‐test) is used to check the statistical significance of the difference between various structural features. The null hypothesis is that the two datasets are different from each other in their cumulative distributions of structural properties in −150 to −1 region relative to TSS (shown in Figure S1). The P‐values, at a significance level of P ≤ 0.001 suggest that all four structural features, average free energy, bendability (calculated using two models, DNase 1 sensitivity, and nucleosome positioning preference) and curvature are significantly different in all six systems, except for curvature in S. cerevisiae.