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. Author manuscript; available in PMC: 2018 Apr 20.
Published in final edited form as: Gene. 2017 Jan 27;609:28–37. doi: 10.1016/j.gene.2017.01.019

Figure 6. Differentially expressed epigenetic regulators during osteogenic differentiation of MSCs.

Figure 6

RT-qPCR expression analysis of all epigenetic regulators and phenotypic genes was performed during an osteogenic time-course (D0, D3, D6, and D11) in MSCs (female patient #258, n = 3). Markers of osteogenic differentiation (ALPL, COL1A1, and TNFRSF11B) are up-regulated, while chondrogenic differentiation markers (SOX9 and COL10A1) are down-regulated during osteogenic differentiation of MSCs (A). Heat-map showing the expression trend of robustly expressed epigenetic regulators (n = 258) in differentiating MSCs (value >0.1 with GAPDH set at 100, out of a total of set of mRNAs of n = 321) (B). Expression pattern of HDAC in undifferentiated (D0) and differentiating (D6) MSCs (C). LE = low expression (<0.01, GAPDH = 100).