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. 2017 Mar 6;7:43709. doi: 10.1038/srep43709

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Shown is the flowchart of present work. SNPs in linkage disequilibrium with 65 T2D risk SNPs were obtained by FunciSNP. Functional annotations were executed on high LD SNPs (r² > 0.5) by integrating genomic, epigenetic and transcriptomic data. The putative risks result from annotations were employed for the improvement of risk model.