Table 3. Odds ratio and 95% CI of putative risk SNPs (P < 0.05).
| SNPs | Categories | Odds Ratio (95% CI) | P value | Nearest gene |
|---|---|---|---|---|
| rs780094 | Known risk SNP | 1.66 (1.02–2.75) | 4.45E-02 | GCKR |
| rs10203174 | Known risk SNP | 1.21 (1.04–1.39) | 1.10E-02 | THADA |
| rs1496653 | Known risk SNP | 1.33 (1.01–1.76) | 4.46E-02 | UBE2E2 |
| rs13233731 | Known risk SNP | 1.55 (1.03–2.36) | 3.63E-02 | KLF14 |
| rs5215 | Known risk SNP | 1.12 (1.01–1.25) | 2.79E-02 | KCNJ11 |
| rs2793823 | TSS region SNP | 0.77 (0.61–0.98) | 3.26E-02 | ADAM30 |
| rs713113 | TSS region SNP | 1.17 (1.06–1.29) | 1.49E-03 | CCNE2 |
| rs9311910 | Histone modification | 0.77 (0.59–0.98) | 3.78E-02 | MIR548A2 |
| rs11857450 | Histone modification | 1.41 (1.10–1.81) | 7.42E-03 | HMG20A |
| rs1993669 | Histone modification | 1.89 (1.11–3.39) | 2.40E-02 | HMGA2 |
| rs7575024 | Histone modification | 1.16 (1.02–1.32) | 2.42E-02 | THADA |
| rs713113 | Histone modification | 1.19 (1.08–1.30) | 2.00E-04 | CCNE2 |
| rs11178602 | Histone modification | 2.66 (1.15–7.80) | 4.12E-02 | TSPAN8 |
| rs9939973 | Histone modification | 1.18 (1.05–1.34) | 6.96E-03 | FTO |
| rs2260671 | Histone modification | 1.49 (1.00–2.23) | 4.96E-02 | HMGA2 |
| rs2868093 | Histone modification | 1.51 (1.07–2.16) | 2.10E-02 | R3HDML |
| rs5018648 | Histone modification | 0.46 (0.24–0.84) | 1.42E-02 | WFS1 |
The ORs (95% CIs) and P values for type 2 diabetes were calculated using logistic regression analysis in 1989 T2D samples and 3000 healthy controls.