Table 4. Association between TLR2, TLR4, TLR6 and CD14 SNPs for genetic models with the lowest AIC and BIC scores and early- and late-asthma.
| Gene | SNP | Genetic model type | Genotype | Early-onset asthma vs never asthma | Late-onset asthma vs never asthma |
|---|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | ||||
| TLR2 | rs1898830 | Additive | A allele | ref | ref |
| Per G allele | 0.96 (0.78–1.19) | 1.12 (0.87–1.42) | |||
| rs3804100 | Dominant | TT | ref | ref | |
| CT/CC | 1.25 (0.82–1.93) | 0.88 (0.52–1.48) | |||
| rs4969480 | Dominant | AA | ref | ref | |
| AT/TT | 1.12 (0.81–1.56) | 1.17 (0.80–1.71) | |||
| TLR4 | rs1927911 | Recessive | CC/CT | ref | ref |
| TT | 0.80 (0.45–1.45) | 0.87 (0.45–1.69) | |||
| rs4986790 | Dominant | AA | ref | ref | |
| AG/GG | 1.23 (0.75–2.04) | 0.76 (0.40–1.44) | |||
| TLR6 | rs1039559 | Dominant | CC | ref | ref |
| CT/TT | 0.79 (0.56–1.12) | 0.78 (0.53–1.16) | |||
| rs5743810 | Dominant | TT | ref | ref | |
| CT/CC | 0.75 (0.51–1.10) | 0.73 (0.47–1.12) | |||
| CD14 | rs2569190 | Recessive | AA/AG | ref | ref |
| GG | 0.80 (0.58–1.10) | 0.70 (0.48–1.02) | |||
| rs5744455 | Dominant | CC | ref | ref | |
| CT/TT | 0.90 (0.67–1.21) | 1.06 (0.76–1.48) | |||
| rs2915863 | Dominant | TT | ref | ref | |
| CT/CC | 1.13 (0.77–1.67) | 1.29 (0.81–2.05) |
All adjusted for sex, maternal and paternal history of asthma and/or hay fever, and atopy at 7 years.