. 2017 Mar 6;7:43681. doi: 10.1038/srep43681

Table 5. Association between TLR6 polymorphisms in an additive genetic model and childhood farm exposure on early-onset and late-onset asthma.

TLR6 SNP	Early-onset asthma vs. never asthma					Late-onset asthma vs. never asthma
	No childhood farm exposure	Childhood farm exposure	No childhood farm exposure	Childhood farm exposure	p-interaction between SNP and farm exposure	No childhood farm exposure	Childhood farm exposure	No childhood farm exposure	Childhood farm exposure	p-interaction between SNP and farm exposure
	n/N	n/N	OR (95% CI)	OR (95% CI)	p-interaction between SNP and farm exposure	n/N	n/N	OR (95% CI)	OR (95% CI)	p-interaction between SNP and farm exposure
rs1039559
C allele	126/483	22/53	ref	ref	0.009	58/221	4/23	ref	ref	0.38
Per T allele	357/483^*	31/53^*	0.79 (0.44–1.41)	0.34 (0.16–0.73)	0.009	163/221^*	19/23^*	0.77 (0.40–1.47)	0.68 (0.30–1.56)	0.38
rs5743810
T allele	52/311	3/26	ref	ref	0.02	102/488	21/53	ref	ref	0.52
Per C allele	259/311^#	23/26^#	0.77 (0.43–1.36)	0.41 (0.19–0.86)	0.02	386/488^#	32/53^#	0.76 (0.40–1.46)	0.77 (0.34–1.74)	0.52

All models were adjusted for sex, maternal and paternal history of asthma and/or hay fever, and personal history of atopy at baseline.

^*The number represents those with one or two T-alleles.

^#The number represents those with one or two C-alleles.