Table 2. Functional annotation of mammalian PSD proteins absent from the zebrafish synapse.
|
Human |
Rat |
Mouse |
||||
|---|---|---|---|---|---|---|
| Fold change* | P value# | Fold change* | P value# | Fold change* | P value# | |
| Related to vesicle-mediated protein traffic and localization | ||||||
| Regulation of vesicle-mediated transport (GO:0060627) | 3.3 | 1.3E−04 | 3.4 | 1.7E−03 | 2.3 | 3.0E−04 |
| Vesicle-mediated transport (GO:0016192) | 2.9 | 5.8E−10 | 2.4 | 7.1E−03 | 2.2 | 1.7E−12 |
| Cytoplasmic transport (GO:0016482) | 2.9 | 5.0E−06 | 2.6 | 1.9E−02 | 2.0 | 1.2E−04 |
| Establishment of protein localization (GO:0045184) | 2.9 | 1.2E−12 | 2.2 | 1.7E−03 | 2.2 | 2.5E−15 |
| Protein transport (GO:0015031) | 2.8 | 2.7E−10 | 2.3 | 4.1E−03 | 2.2 | 3.5E−14 |
| Intracellular transport (GO:0046907) | 2.7 | 9.9E−10 | 2.5 | 6.3E−06 | 2.2 | 4.0E−15 |
| Endosome (GO:0005768) | 2.2 | 3.3E−02 | 2.5 | 3.2E−03 | 2.3 | 6.8E−10 |
| Related to protein location at plasma membrane | ||||||
| Extrinsic component cytoplasmic side of plasma membrane (GO:0031234) | 5.8 | 2.8E−04 | 5.9 | 5.2E−03 | 3.5 | 9.4E−04 |
| Extrinsic component of plasma membrane (GO:0019897) | 5.1 | 1.1E−04 | 5.3 | 8.1E−04 | 3.3 | 6.5E−05 |
| Cytoplasmic side of plasma membrane (GO:0009898) | 4.5 | 5.3E−04 | 6.1 | 2.6E−06 | 3.7 | 1.1E−07 |
| Cytoplasmic side of membrane (GO:0098562) | 4.2 | 1.4E−03 | 5.7 | 7.7E−06 | 3.5 | 2.1E−07 |
| Extrinsic component of membrane (GO:0019898) | 3.3 | 6.3E−03 | 3.6 | 1.1E−02 | 2.5 | 2.8E−04 |
| Related to actin filaments organization | ||||||
| Regulation of actin filament length (GO:0030832) | 4.6 | 2.8E−03 | 4.8 | 1.7E−02 | 2.9 | 9.7E−03 |
| Actin cytoskeleton organization (GO:0030036) | 4.0 | 1.8E−08 | 3.3 | 3.7E−03 | 2.4 | 7.9E−06 |
| Actin filament-based process (GO:0030029) | 4.0 | 1.3E−09 | 3.4 | 5.9E−04 | 2.6 | 3.8E−08 |
| Regulation of cytoskeleton organization (GO:0051493) | 3.4 | 8.1E−06 | 3.2 | 3.9E−03 | 2.7 | 3.0E−09 |
| Related to cation transport | ||||||
| Regulation of cation transmembrane transport (GO:1904062) | 4.4 | 1.1E−04 | 4.6 | 1.2E−03 | 2.7 | 2.7E−03 |
| Regulation of metal ion transport (GO:0010959) | 3.0 | 2.3E−02 | 3.4 | 1.7E−02 | 2.2 | 4.2E−03 |
| Transmembrane transporter complex (GO:1902495) | 3.0 | 2.8E−02 | 3.4 | 1.1E−02 | 2.7 | 5.0E−06 |
| Transporter complex (GO:1990351) | 2.9 | 3.8E−02 | 3.3 | 1.5E−02 | 2.7 | 1.2E−06 |
| Related to cell junction | ||||||
| Adherens junction (GO:0005912) | 3.9 | 1.8E−09 | 3.3 | 2.1E−04 | 2.2 | 1.3E−04 |
| Cell–substrate junction (GO:0030055) | 3.9 | 1.1E−07 | 3.7 | 3.8E−05 | 2.0 | 1.7E−02 |
| Anchoring junction (GO:0070161) | 3.7 | 6.3E−09 | 3.3 | 1.3E−04 | 2.2 | 9.8E−05 |
| Cell junction (GO:0030054) | 2.9 | 2.0E−13 | 3.0 | 3.0E−12 | 2.4 | 2.1E−22 |
GO, Gene Ontology; PSD, postsynaptic density.
*Fold enrichment of observed proteins per GO term.