Figure 4. Inactivation of EphB6 does not affect intestinal tumorigenesis in mouse models.

(A) No differences were observed in the weight of animals bearing heterozygous Apc mutations and that were wild type, heterozygous or knockout for EphB6 (Student’s t-test p > 0.6). (B) No differences were observed in the survival of Apc^min/+ mice when either one or two copies of EphB6 were inactivated (logrank test p > 0.27). (C,D) Number and size of the tumors observed in the small and large intestine of 19-week-old Apc^min/+ mice that are EphB6 wild type, heterozygous or knockout. The number of animals per group (n) is shown. (E and F) Number and size of intestinal tumors by EphB6 genotype in the AOM model. (G,H) Representative micrographs of the normal small intestine stained with Hematoxylin and eosin at low and high magnification, respectively. Histology of a representative adenoma (I,J), carcinoma in situ (K,L) and infiltrating carcinoma (M,N).