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. 2017 Mar 6;7:43702. doi: 10.1038/srep43702

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A,B) Tail-vein injection of LIM2405 cells resulted in the formation of lung metastasis that were confirmed by Hematoxylin and eosin staining of histological sections of formalin-fixed, paraffin-embedded lungs (N: normal; T: tumor). A significant reduction in the number of lung metastasis was observed in the lungs of mice injected with isogenic EPHB6-overexpressing LIM2405 cells (LIM2405-EPHB6) compared to mice injected with the LIM2405-EV control cells. (C,D) EPHB6 knockdown in SW480 cells resulted in a significant increase in the number of metastatic lesions compared to control cells (non-target shRNA cells –shNT) in the lungs of NOD/SCID animals after tail-vein injection. The mean ± SEM is shown in panels (A) and (C). N: number of animals. Asterisks indicate statistically significant differences (Student’s t-test p < 0.05).