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. 2017 Mar 3;8:14639. doi: 10.1038/ncomms14639

Figure 6. Zyxin-mediated endothelial exocytosis is required for vascular thrombosis and haemostasis in mice.

Figure 6

(a) The scheme of cross marrow transplantation for Zyxin BC and Zyxin EC mice. (b) Normalized level of plasma VWF in WT (n=12), Zyxin KO (n=12), Zyxin EC (n=12) and ZyxinBC (n=8) mice after epinephrine (EPI) stimulation (*P<0.05, ***P<0.001). (c) Blood bleeding time of WT (n=12), Zyxin KO (n=12), Zyxin EC (n=11) and ZyxinBC (n=12) mice after epinephrine stimulation (***P<0.001, NS>0.05). (d) Thrombus formation in the mesenteric vessels of WT (n=11), Zyxin KO (n=11), Zyxin EC (n=8) and ZyxinBC (n=8) mice. The thrombus is indicated with Rhodamine-labelled platelets and FITC-conjugated anti-VWF antibody. The graph showed the coverage of the area in the thrombus-formation assay. (***P<0.001, NS>0.05). All error bars represent s.e.m. Student's t-test was used for statistical analysis.