Table 2. HLA-DRB1 alleles distribution in patients with type 1 diabetes and health controls.

DRB1	T1D	Controls	OR	CI 95%	p	p
alleles	n (%)	n(%)			no-structured	structured
1	119 (8.5%)	158 (10.5%)	0.79	(0.62–1.02)	0.062	0.108
301	400 (28.7%)	121 (8.1%)	4.58	(3.68–5.69)	<0.0001	<0.001
302	1 (0.1%)	20 (1.3%)	0.05	(0.01–0.39)	<0.0001	<0.001
401	127 (9.1%)	52 (3.5%)	2.79	(2.00–3.90)	<0.0001	<0.001
402	98 (7.0%)	27 (1.8%)	4.12	(2.67–6.35)	<0.0001	<0.001
403	7 (0.5%)	11 (0.8%)	0.68	(0.26–1.76)	0.578	—
404	38 (2.7%)	21 (1.4%)	1.97	(1.15–3.37)	0.0119	0.007
405	142 (10.2%)	18 (1.2%)	9.32	(5.68–15.31)	<0.0001	<0.001
407	3 (0.2%)	8 (0.5%)	0.4	(0.1–1.5)	0.1639	0.1345
408	4 (0.3%)	7 (0.5%)	0.61	(0.2–2.1)	0.4310	0.5316
411	3 (0.2%)	9 (0.6%)	0.36	(0.09–1.32)	0.186	0.1070
7	79 (5.7%)	177 (11.8%)	0.45	(0.34–0.59)	<0.0001	<0.001
8	47 (3.4%)	85 (5.7%)	0.58	(0.40–0.83)	0.0030	0.012
9	51 (3.7%)	21 (1.4%)	2.67	(1.59–4.46)	<0.0001	<0.001
10	10 (0.7%)	33 (2.2%)	0.32	(0.16–0.65)	0.0010	0.002
11	53 (3.8%)	159 (10.6%)	0.33	(0.24–0.46)	<0.0001	<0.001
12	13 (0.9%)	24 (1.6%)	0.58	(0.29–1.14)	0.1093	0.168
13	93 (6.7%)	207 (13.8%)	0.45	(0.34–0.58)	<0.0001	<0.001
14	14 (1.0%)	70 (4.7%)	0.21	(0.12–0.37)	<0.0001	<0.001
15	28 (2.0%)	177 (11.8%)	0.15	(0.10–0.23)	<0.0001	<0.001
16	28 (2.0%)	59 (3.9%)	0.5	(0.32–0.79)	0.0024	0.001
Others	45 (3.2%)	51 (3.4%)

Association with Type 1 diabetes before and after correction for population stratification T1D = type 1 diabetes mellitus; n = number of individuals; OR = odds ratio; CI = confidence interval; p no-structured = significance level before STRAT analysis; p structured = significance level after STRAT analysis.

Twenty-one alleles with total number in patients plus controls greater than 10 (0.4%) were included. P required for statistical significance after Bonferroni correction for multiple tests <0.0023. Rare alleles were included in others.