Table 4. HLA-DRB1/DRB1 genotypes distribution in patients with type 1 diabetes mellitus and controls.
| Genotypes | T1D n(%) | Controls n(%) | OR | CI 95% | p no-strutured | p structured |
|---|---|---|---|---|---|---|
| DR3/DR3 | 61 (8.7%) | 8 (1.1%) | 8.88 | (4.22–18.70) | <0.0001 | <0.001 |
| DR3/DR4 | 167 (23.9%) | 14 (1.9%) | 16.53 | (9.48–28.85) | <0.0001 | <0.001 |
| DR3/DR9 | 18 (2.6%) | 4 (0.5%) | 4.94 | (1.66–14.66) | 0.0015 | 0.002 |
| DR3/DRX | 110 (15.8%) | 120 (16.0%) | 0.98 | (0.74–1.30) | 0.9004 | 0.802 |
| DR4/DR4 | 42 (6.0%) | 10 (1.3%) | 4.74 | (2.36–9.52) | <0.0001 | <0.001 |
| DR4/DR9 | 12 (1.7%) | 5 (0.7%) | 2.61 | (0.91–7.44) | 0.0632 | 0.105 |
| DR4/DRX | 181 (25.9%) | 137 (18.3%) | 1.57 | (1.22–2.01) | 0.0004 | 0.002 |
| DR9/DR9 | 1 (0.1%) | 0 (0.0%) | — | — | 0.2998 | — |
| DR9/DRX | 19 (2.7%) | 12 (1.6%) | 1.72 | (0.83–3.57) | 0.1405 | 0.159 |
| DRX/DRX | 87 (12.5%) | 440 (58.7%) | 0.1 | (0.078–0.13) | <0.0001 | <0.001 |
Association with Type 1 diabetes before and after correction for population stratification T1D = type 1 diabetes mellitus; n = number of individuals; OR = odds ratio; CI = confidence interval; p no-structured = level of significance before strat analysis; p structured = level of significance after strat analysis. P required for statistical significance after a Bonferroni correction for multiple tests −<0.005.