Table 1.
Chemicals Identified in Common Flavored Electronic Nicotine Delivery System e-Liquids by Gas Chromatography–Mass Spectrometry
| Flavored e-liquid | Nicotine concentration (mg/mL) labeled | Chemicals identified | Chemical synonym | CAS registry number | Quality scores |
|---|---|---|---|---|---|
| Classic Tobacco | 0 | Butanoic acid | Cinnamyl isovalerate | 107-92-6 | 58 |
| Classic Tobacco | 24 | 3-(1-Methyl-2-pyrrolidinyl)pyridine | Nicotine | 54-11-5 | 91 |
| β-Nicotyrine | 487-19-4 | 94 | |||
| 3-methyl-1-phenyl-1H-pyrazole | 1128-54-7 | 91 | |||
| Butanoic acid | Cinnamyl isovalerate | 107-92-6 | 68 | ||
| Cinnamon Roll | 0 | 1,2,3-Propanetriol, triacetate | 102-76-1 | 78 | |
| 1,2,3-Propanetriol, diacetate | 25395-31-7 | 53 | |||
| Benzaldehyde 4-hydroxy-3-methoxy- | Vanillin | 121-33-5 | 96 | ||
| 3-Ethoxy-4-hydroxybenzaldehyde | Ethyl vanillin | 121-32-4 | 80 | ||
| 2-Methoxy-4-propylphenol | 2785-87-7 | 50 | |||
| Cinnamaldehyde propylene glycol acetal | 4353-01-9 | 83 | |||
| 2H-1-Benzopyran-2-one, 6-methyl- | 92-48-8 | 95 | |||
| 2H-1-Benzopyran-2-one, 7-methyl- | 2445-83-2 | 94 | |||
| 2H-1-Benzopyran-2-one, 3-methyl- | 2445-82-1 | 81 | |||
| Heliotropin propylene glycol acetal | 61683-99-6 | 95 | |||
| Vanillin propylene glycol hemiacetal | 68527-74-2 | 50 | |||
| Cotton Candy | 0 | 2-Ethyl-3-hydroxy-4-pyrone | Ethyl maltol | 4940-11-8 | 87 |
| N-ethylidenehexahydro-1H-azepin-1-amine | 75268-01-8 | 64 | |||
| 3-Ethoxy-4-hydroxybenzaldehyde | Ethyl vanillin | 121-32-4 | 87 | ||
| Ethyl vanillin propylene glycol acetal | 68527-76-4 | 59 | |||
| Clove | 18 | 3-(1-Methyl-2-pyrrolidinyl)pyridine | Nicotine | 54-11-5 | 91 |
| 2,methoxy-4-(2-propenyl)phenol | Synthetic clove oil | 97-53-0 | 97 | ||
| Café Cubano | 18 | 3-(1-Methyl-2-pyrrolidinyl)pyridine | Nicotine | 54-11-5 | 91 |
| Coffee | 18 | 3-(1-Methyl-2-pyrrolidinyl)pyridine | Nicotine | 54-11-5 | 91 |
| Grape Vape | 0 | 2-aminobenzoic acid methyl ester | Methyl anthranilate | 134-20-3 | 95 |
| 3-(1-Methyl-2-pyrrolidinyl)pyridine | Nicotine | 54-11-5 | 91 | ||
| Melon Mania | 0 | Phenol-d5 | 4165-62-2 | 64 | |
| 1-(Ethenyloxy)pentane | 5363-63-3 | 59 | |||
| Dihydro-4,4-dimethyl-2(3H)-furanone | 13861-97-7 | 59 | |||
| Dihydro-5-pentyl-2(3H)-furanone | 104-61-0 | 78 | |||
| 5-butyldihydro-2(3H)-furanone | γ-Octanoic lactone | 104-50-7 | 72 | ||
| Mountain Du Voltage | 18 | 3-(1-Methyl-2-pyrrolidinyl)pyridine | Nicotine | 54-11-5 | 91 |
| Benzenemethanol | Benzyl alcohol | 100-51-6 | 95 | ||
| β-Nicotyrine | 487-19-4 | 95 | |||
| 2,6-Dimethyl-1,8-naphthyridine | 14757-45-0 | 68 | |||
| 3-methyl-1-phenyl-1H-pyrazole | 1128-54-7 | 64 | |||
| Strawberry Fields | 0 | Benzenemethanol | Benzyl alcohol | 100-51-6 | 96 |
| Benzaldehyde propylene glycol acetal | 2568-25-4 | 60 | |||
| Strawberry Zing | 0 | Benzenemethanol | Benzyl alcohol | 100-51-6 | 96 |
| Benzaldehyde propylene glycol acetal | 2568-25-4 | 96 | |||
| 2-Propenoicacid,3-phenyl-,methylester;3-phenyl- | Methyl cinnamate | 103-26-4 | 87 | ||
| Phenyl-2-propenoic acid methyl ester | Methyl trans-cinnamate | 1754-62-7 | 87 | ||
| 5-hexyldihydro-2(3H)-furanone,4-decanolide | 706-14-9 | 72 | |||
| 5-butyl dihydro-2(3H)-furanone | γ-Octanoic lactone | 104-50-7 | 72 | ||
| 2(3H)-Furanone, 5-heptyldihydro | Peach aldehyde | 104-67-6 | 86 | ||
| 2(3H)-Furanone, 5-hexyldihydro- | 706-14-9 | 83 | |||
| Dihydro-5-pentyl-2(3H)-furanone | 104-61-0 | 83 | |||
| 2,6-dimethyl-4-propylpyridine | 65061-78-1 | 53 | |||
| 2-ethoxy-1-(3′ pyridyl) ethylene | 13362-78-2 | 50 | |||
| Benzyl benzoate | 120-51-4 | 97 |